摘要
目的探讨检测孕中期母血清中AFP,β-HCG浓度对筛查唐氏综合症胎儿的作用。方法利用微粒子酶免疫技术检测血清中甲胎蛋白(AFP)和绒毛膜促性腺激素(β-HCG)的浓度．结合各种影响因素,利用分析软件进行风险评估,再经羊水细胞染色体核型分析确诊。结果3617例孕中期孕妇接受筛查,唐氏综合症高危者219例,阳性率6．1%。219例高危者中的178例接受羊水染色体检查。共查出染色体异常6例,其中唐氏综合证3例。结论孕中期母血清中AFP,β-HCG的测定是一种无创性检测手段,对筛查唐氏综合症胎儿,减少其出生有重要意义。
Objective To analyze the effect of AFP and β- HCG in serum of the pregnant women at the second trimester on the screening of foetus with Down syndrome. Methods The concentration of AFP and β-HCG in serum were tested by microparticle enzyme. On the basis of some kinds of influencing factors, the risk assessment was made using analytical software. Down syndrome was finally diagnosed by analysis of chromosome in the cell of amniotic fluid. Results 3 617 pregnant women at second trimester of pregnancy were screened and 219 were at high risk of Down syndrome with a positive rate of 6.1%. Test of chromosome in the anmi- otie fluid cells of 178 high risk Down syndrome women was performed and chromosomal abnormality was observed in 6 of them and 3 were conformed to be with Down syndrome. Conclusion The analysis of AFP and β- HCG in serum for diagnosis is safe, effective and simple for diagnosis of foetus with Down syndrome.
出处
《中国热带医学》
CAS
2007年第1期91-92,共2页
China Tropical Medicine
关键词
唐氏综合症
产前筛查
羊水诊断
Down syndrome
Antepartum screen
Amniofic fluid
