摘要
目的研究肝硬变门静脉高压症(PHT)患者外周血浆尾加压素Ⅱ(UⅡ)水平的变化以及与肝功能的关系。方法用放射免疫学方法分别测定21例健康对照者和29例PHT患者(按肝功能Child-Pugh分级将病例分为A,B,C 3组)外周血浆中UⅡ的含量,并进行相互比较。结果PHT患者外周血浆UⅡ水平[(1.821±0.020)pg/ml]低于对照组[(1.973±0.016)pg/ml],其差异有统计学意义(t=-3.190,P<0.01),且随着肝功能的恶化,UⅡ水平逐步降低(r=-0.401,P<0.05)。结论UⅡ与肝硬化门静脉高压症的发生发展可能存在一定的联系,其内在机制尚待进一步研究。
Objective To investigate the changes of plasma level of urotonsin Ⅱ （U Ⅱ ） in the cin＇hotic patients withportal hypertension（PHT） and the relation to liver function. Methods The plasma.level of UⅡ was measured with radioimmnnoassay in 21 controls and in 29 PHT patients divided into group A,B and C respectively according to the Child- Pugh liver function grading. Results The plasma level of U Ⅱ was lower （ t = - 3. 190, P 〈 0.01 ） in PHT patients [ （1.821 ± 0.020）pg/ml] than that in the controls [ （1.973 ± 0.016）pg/ml] and decreased with the severity of hepatic function impairment （ r = - 0. 401, P 〈 0. 05）. Conclusion It is possible there is definte correlation between U Ⅱ and the cirrhotic portal hypertension,however, the mechanism remains to be further studied.
出处
《肝胆胰外科杂志》
CAS
2006年第6期350-351,354,共3页
Journal of Hepatopancreatobiliary Surgery
关键词
尾加压素Ⅱ
高血压
门静脉
肝硬化
urotensin Ⅱ
hypertension, portal vein
liver cirrhosis
