摘要
机会性致病原虫在HIV感染者中是最重要的致病与致死的原因之一。自20世纪后期高效抗逆转录病毒疗法(HAART)问世后,机会性致病寄生虫的感染率明显下降。非核苷类逆转录酶抑制剂、HIV蛋白酶抑制剂及核苷类逆转录酶抑制剂这3类药物中,至少2种联合应用的HAART,对细胞免疫的下降有恢复作用,也有证据表明HIV蛋白酶抑制剂对寄生虫的蛋白酶有直接抑制作用。
Opportunistic protozoa infections are an important cause of morbidity and mortality in patients infected with HIV. Since the introduction of highly active antiretroviral therapy （ HAART）, there has been a marked reduction in rate of these parasitic infections. HAART in combination with at least two drugs a- mong non-nucleoside reverse transcriptase inhibitors, HIV protease inhibitors and nucleoside reverse transcriptase inhibitors, is effective in the restoration of cell-mediated immunity. There is evidence that HIV protease inhibitors have a direct inhibitory effect on the protease of opportunistic protozoa.
出处
《国际医学寄生虫病杂志》
CAS
2006年第6期305-308,共4页
International JOurnal of Medical Parasitic Diseases
