摘要
目的:建立尿液样品中氯胺酮及其代谢物去甲氯胺酮、去氢去甲氯胺酮、脱氢去甲去氨氯胺酮的快速提取及气相-质谱(GC-MS)分析方法。方法:尿液用10%碳酸钠调节pH=9～10,乙醚液液萃取,GC-MS分析。结果:该方法可快速检测氯胺酮滥用者尿液中的氯胺酮原体及三个代谢物,同时检测包括苯丙胺类药物在内的其它药物。结论:该方法可快速进行氯胺酮滥用者尿液的分析。
Objective： To establish a simple extract and analytical methods of the metabolits of ketamine in human urine. Methods： 1 ml of urine is extracted with 5 ml of ether, adding Na2CO3 solution （10% aq.） to adjust pH = 9-10. The extractive is analysed by GC-MS. Results： Ketamine and its three metabolits NK, DHNK, DHDANK can be detected by the analytical methods. Other 7 kinds of drugs including MA, MDMA, MDA etc. can also be detected simultaneously. Condusion： The methods are suitable for the analysis of the urine specimens of new drug abuse style. The data of the metabolites suggest that there may be a correlation between the ratio of the three metabolites of ketamine and the time in which the specimens being collected.
出处
《中国药物滥用防治杂志》
CAS
2006年第6期330-332,共3页
Chinese Journal of Drug Abuse Prevention and Treatment
