摘要
目的:探讨干扰素γ(IFN-γ)和转化生长因子β1(TGF-β1)在慢性前列腺炎/慢性骨盆疼痛综合征(CP/CPPS)患者前列腺液中的临床意义。方法:采用双抗体夹心法对20例炎症性慢性骨盆疼痛综合征(ⅢA)、20例非炎症性慢性骨盆疼痛综合征(ⅢB)、10例健康对照者前列腺按摩液(EPS)中IFN-γ、TGF-β1含量进行测定。并与患者的美国国立卫生研究院慢性前列腺炎症状指数(NIH-CPSI)进行相关性研究。结果:IFN-γ、TGF-β1在ⅢA[(14.92±7.85)、(8 477.50±4 612.45)ng/L]和ⅢB[(13.74±5.96)、(7 946.50±5 044.06)ng/L]患者EPS中水平均明显高于健康对照组[(7.47±1.49)、(2 462.50±985.31)ng/L](P<0.05和P<0.001)。但在ⅢA和ⅢB之间差异无显著性(P>0.05)。EPS中IFN-γ、TGF-β1的水平与慢性前列腺炎症状指数无相关性(r=0.02,P=0.86;r=0.31,P=0.76)。结论:前列腺液中细胞因子IFNγ-、TGF-β1在CP/CPPS的病理学改变中可能起重要作用,可作为CP/CPPS的诊断依据之一。
Objective： To investigate the levels of pro-inflammatory cytokine IFN-γ and anti-inflammatory cytokine TGF-β1 in the expressed prostatic secretion （EPS） of men with chronic abacterial prostatitis and their clinical significance. Methods： The levels of IFN-γ and TGF-β1 in the EPS of 20 patients with inflammatory chronic pelvic pain syndrome （type ⅢA） , 20 patients with non-inflammatory chronic pelvic pain syndrome （type Ⅲ B） and 10 healthy men were measured using enzyme-linked immunosorbent assay （ELISA）. The results were analysed comparatively with NIH-chronic prostatitis symptom index（NIH-CPSI）. Results： IFN-γ and TGF-β1 levels were higher in IliA（ [14.92±7.85） ], [8 477.50 ± 612.45] ng/L） and IllB（[13.74±5.96], [7 946.50±5 044.06 ] ng/L） prostatitis patients than those in the controls （ [ 7.47±1.49 ], [ 2 462.50 ± 985.31 ] ng/L）, P 〈 0.05 and P 〈 0. 001 respectively. There was no statistically significant difference in cytokine levels between ⅢA and ⅢB prostatitis patients. No correlation was found between NIH-CPSI and cytokine levels, r = 0.02, P = 0.86, r = 0.31, P = 0.76. Conclusion ： IFN-γ and TGF- β1 play a very important role in the etiology of chronic abactefial prostatitis and can be the objective parameters in the diagnosis of chronic abacterial prostatitis.
出处
《中华男科学杂志》
CAS
CSCD
2006年第11期982-984,共3页
National Journal of Andrology
基金
湖北省人口和计划生育委员会课题(301140220)
