摘要
背景:射频消融能触发犬的心肌神经再生和交感神经再支配,其对人体也可能有同样的作用。神经生长因子是一种神经营养因子,能够促进交感神经的生长和分化,改善靶器官的神经支配。目的:证实射频消融能提高人神经生长因子的浓度的假设。设计:自身对照实验。单位:解放军第四军医大学唐都医院心内科。材料:选择2005-01/06在解放军第四军医大学唐都医院心内科行房室结折返性心动过速(n=18)、右侧旁道(n=13)和左侧旁道(n=12)射频消融治疗的患者43例,男20例,女23例;年龄28～65岁。所有患者对实验均知情同意。方法:于射频消融前和消融后6h,1,3,5,7d抽取患者静脉血,用酶联吸附免疫分析法测量射频消融前和射频消融后不同时间点的血浆神经生长因子浓度。主要观察指标:酶联吸附免疫吸附法测量的射频消融前和消融后6h,1,3,5,7d神经生长因子浓度。结果:纳入患者43例,均进入结果分析。射频消融后6h神经生长因子开始增高并且持续增高到第7天。房室结折返性心动过速、右侧旁道和左侧旁道射频消融治疗的患者射频消融后6h,1,3,5,7d的神经生长因子浓度分别为(29.72±7.04),(30.94±5.68),(31.39±4.92),(31.06±4.56),(29.11±4.59),(31.77±6.25),(30.69±5.10),(31.46±4.96),(30.15±4.01),(30.43±3.14),(31.42±6.75),(31.00±5.20),(32.08±4.62),(30.67±3.71),(29.27±2.75)μg/L,均明显大于射频消融前[(14.89±2.84),(15.00±2.71),(15.51±2.75)μg/L,P<0.01]。但射频消融后各时间点的神经生长因子浓度差异不明显,房室结折返性心动过速、右侧旁道和左侧旁道射频消融治疗的患者在同一时间点的神经生长因子浓度差异不明显(P>0.05)。神经生长因子浓度的改变与房室结折返性心动过速、右侧旁道和左侧旁道射频消融的手术时间、次数和总的消融能量均无显著性相关(P>0.05)。结论:射频消融能提高人神经生长因子的浓度,神经生长因�
BACKGROUND： Radiofrequency catheter ablation （RFCA） in dog triggers myocardial nerve sprouting and sympathetic hyperinnevation. It is possible that RFCA in humans has the same effect. Nerve growth factor （NGF） is a neurons nurture that supports the survival and differentiation of sympathetic neurons and enhances target innervation. Therefore, it is hypothetic that RFCA can increases plasma NGF concentration in humans. OBJECTIVE： To test the hypothesis that RFCA increases plasma NGF concentration in humans. DESIGN： Self-control experiment. SETTING： Department of Cardiology, Tangdu Hospital, the Fourth Military Medical University of Chinese PLA. PARTICIPANTS： Forty-three patients were selected from the Cardiological Department of Tangdu Hospital, the Fourth Military Medical University of Chinese PLA from January to June 2005, including atrioventricular nodal reentrant tachycardia （AVNRT） （n=18）, right-sided accessory pathways （RSAP） （n=13） and left-sided accessory pathways （LSAP） （n=12）, 20 males and 23 females, ages 28-65 years, all agreed to participate in the study voluntarily. METHODS： Blood samples were obtained from the peripheral veins before ablation and at 6 hours, 1, 3, 5, 7 days after ablation. The plasma concentration of NGF was determined with enzyme-linked immunosorbent assay （ELISA）. MAIN OUTCOME MEASURES： The plasma concentration of NGF was determined with ELISA before RFCA and at 6 hours, 1, 3, 5, 7 days after RFCA in each patient. RESULTS： Total 43 patients who were referred for ablation therapy for AVNRT, RSAP and LSAP were involved in the result analysis without loss. Plasma NGF increased at 6 hours after RFCA. Increased NGF continued to 7 days in the RFCA treated patients. The plasma NGF concentrations at 6 hours, 1, 3, 5, 7 days after RFCA in AVNRT, RSAP and LSAP ablations treated patients were （29.72±7.04）, （30.94±5.68）, （31.39±4.92）, （31.06 ±4.56）, （29.11±4.59）, （31.77 ±6.25）, （30.69 ±5.10）, （31.46±4.96
出处
《中国临床康复》
CSCD
北大核心
2006年第45期187-189,共3页
Chinese Journal of Clinical Rehabilitation
