摘要
目的:研究中药四君子汤对肠道菌群失调小鼠的调节作用和肝细菌易位的抑制作用。方法:小鼠经γ射线造成菌群失调模型。将小鼠分为正常对照组,自然恢复组,丽珠肠乐组,四君子汤组。治疗后,进行肠道菌群检测,组织病理学检测,肝脏细菌易位检测。结果:四君子汤组肠道正常菌群量大幅度增加,肝脏细菌易位减少,与自然恢复组相比差异显著,肠道粘膜损伤的修复比自然恢复组好。结论:四君子汤能够促进肠粘膜损伤恢复,调节肠道菌群失调,抑制肝脏细菌易位。
Objective：To study the regulation of Sijunzitong in intestinal flora of radiated mouse and the inhibition of bacterial translocation in the liver. Methods： We used γ-ray to prepare a mouse flora imbalance model. The mice were divided into four groups：normal control group, natural recovery group, Lizhuehangle group, Sijunzitong group. We carried out pathological examination and intestinal flora detection and bacterial transloeation detection after therapy. Results：The number of normal intestinal flora significantly increased and bacterial transloeation decreased and intestinal mueosa injury recovered better in Sijunzitong group, compared with those in natural recovery group. Conclusion： Sijunzitong can promote intestinal mucosa recovery and regulate intestinal flora imbalance and decrease bacterial transloeation.
出处
《黑龙江医药科学》
2006年第6期49-50,共2页
Heilongjiang Medicine and Pharmacy
关键词
四君子汤
菌群失调
细菌易位
Sijunzitang
alternation of intestinal flora
bacterial translocation
