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γH2AX的检测方法简介 被引量：5

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作者 余艳柯 朱心强 杨军
机构地区 浙江大学公共卫生学院毒理系
出处 《毒理学杂志》 CAS CSCD 北大核心 2006年第6期408-410,共3页 Journal of Toxicology
基金 国家高技术863研究发展计划(2004AA649120) 国家自然科学基金(30471956) 霍英东高校青年教师基金(101036) 教育部新世纪优秀人才支持计划(NCET-05-0520)
关键词 γH2AX 免疫荧光 流式细胞技术 免疫印迹
分类号 R113 [医药卫生—公共卫生与预防医学]
  • 相关文献

参考文献15

  • 1Wang H,Wang M,Bocker W,et al.Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors.J Cell Physiol,2005,202:492-502. 被引量：1
  • 2余艳柯,陆源,余应年,杨军.γH2AX:DNA双链断裂的标志[J].中国药理学与毒理学杂志,2005,19(3):237-240. 被引量：15
  • 3Redon C,Pilch D,Rogakou E,et al.Histone H2A variants H2AX and H2AZ.Curr Opin Genet Dev,2002,12:162-169. 被引量：1
  • 4Ward IM,Chen J.Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress.J Biol Chem,2001,276:47759-47762. 被引量：1
  • 5Paull TT,Rogakou EP,Yamazaki V,et al.A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.Curr Biol,2000,10:886-895. 被引量：1
  • 6Fernandez-Capetillo O,Chen HT,Celeste A,et al.DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.Nat Cell Biol,2002,4:993-997. 被引量：1
  • 7Celeste A,Petersen S,Romanienko PJ,et al.Genomic instability in mice lacking histone H2AX.Science,2002,296:922-927. 被引量：1
  • 8Celeste A,Difilippantonio S,Difilippantonio MJ,et al.H2AX haploinsufficiency modifies genomic stability and tumor susceptibility.Cell,2003,114:371-383. 被引量：1
  • 9Celeste A,Fernandez-Capetillo O,Kruhlak MJ,et al.Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.Nat Cell Biol,2003,5:675-679. 被引量：1
  • 10Rothkamm K,Lobrich M.Evidence for a lack of DNA doublestrand break repair in human cells exposed to very low x-ray doses.Proc Natl Acad Sci U S A,2003,100:5057-5062. 被引量：1

二级参考文献23

  • 1Yang J, Yu Y, Duerksen-Hughes PJ. Protein kinases and their involvement in the cellular responses to genotoxic stress[J]. Mutat Res,2003, 543(1):31-58. 被引量：1
  • 2Fischle W, Wang Y, Allis CD. Histone and chromatin cross-talk[J].Curr Opin Cell Biol, 2003, 15(2) : 172 - 183. 被引量：1
  • 3Chadwick BP, Willard HF. Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant[J]. Hum ,Mol Genet, 2001, 10(10):1101-1113. 被引量：1
  • 4Redon C, Pilch D, Rogakou E, Sedelnikova O, Newrock K, Bonner W. Histone H2A variants H2AX and H2AZ[J]. Curr Opin Genet Dev, 2002, 12(2) : 162 - 169. 被引量：1
  • 5Wang H, Wang M, Wang H, Bocker W, fiiakis G. Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated ruth kinase inhibitors[J]. J Cell Physiol, 2005, 202(2):492-502. 被引量：1
  • 6Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139[J]. J Biol Chem, 1998, 273(10):5858-5868. 被引量：1
  • 7MacPhail SH, Banath JP, Yu TY, Chu EH, Lambur H, Olive PL.Expression of phosphorylated histone H2AX in cultured cell lines following exposure to X-rays[J]. Int J Radiat Bid, 2003, 79(5):351 - 358. 被引量：1
  • 8Rothkamm K, Lobrich M. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low X-ray doses[J]. Proc Natl Aoad Sci U S A. 2003, 100(9):5057-5062. Epub 2003 Apr 04. 被引量：1
  • 9Downs JA, Lowndes NF, Jackson SP. A role for Saccharomryces cerevisiae histone H2A in DNA repair[J]. Nature, 2000, 408(6815):1001 - 1004. 被引量：1
  • 10Ward IM, Chen J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress[J]. J Biol Chem,2001, 276(51):47759-47762. Epub 2001 Oct 22. 被引量：1

共引文献14

同被引文献55

  • 1吕兰海,杨陟华,尤汉虎,曹珍山,刘兴荣,朱茂祥.卷烟烟气及其主要有害成分诱发细胞基因突变的研究[J].环境与健康杂志,2004,21(5):286-288. 被引量：16
  • 2王保红,鲁德强,金力奋,郑伟,楼建林,邓红平,李晴宇,何继亮.1.8GHz微波对四种化学诱变剂致DNA的损伤作用[J].中华劳动卫生职业病杂志,2005,23(3):163-166. 被引量：4
  • 3余艳柯,陆源,余应年,杨军.γH2AX:DNA双链断裂的标志[J].中国药理学与毒理学杂志,2005,19(3):237-240. 被引量：15
  • 4刁汇玲,周春仙,余艳柯,杨军.2-乙酰氨基芴诱导γH2AX焦点的形成[J].中国药理学与毒理学杂志,2006,20(2):131-137. 被引量：7
  • 5王保红,鲁德强,金力奋,陈士杰,楼建林,郑伟,何继亮.1．8GHz微波对紫外线诱发的人淋巴细胞DNA损伤效应的影响[J].中华劳动卫生职业病杂志,2007,25(8):470-472. 被引量：2
  • 6CAI X Y, LIU W P, SHENG G Y. Enantioselective degradation and ecotoxicity of the chiral herbicide diclofop in three freshwater alga cultures[ J ]. Journal of Agricultural and Food Chemistry, 2008, 56(6) :2139-2146. 被引量：1
  • 7MARVIN C H, TOMY G T, ARMITAGE J M, et al. Hexabremocyclododecane: Current understanding of chemistry, environmental fate and toxicology and implications for global management [ J ]. Environmental Science & Technology, 2011, 45 (20) :8613-8623. 被引量：1
  • 8HEEB N V, SCHWEIZER W B, MATTREL P, et al. Regio and stereoseleetive isomerization of hexabromoeyclododecanes (HBCDs) : Kinetics and mechanism of y-to a-HBCD isomerization [ J]. Chemosphere, 2008, 71 (8) : 1547-1556. 被引量：1
  • 9GUERRA P, ELJARRAT E, BARCELO D. Enantiomerie specific determination of hexabromoeyelododecane by liquid chromatography- quadrupole linear ion trap mass speetremetry in sediment samples[ J]. Journal of Chromatography A, 2008, 1203 ( 1 ) : 81-87. 被引量：1
  • 10GUERRA P, ELJARRAT E, BARCELO D. Simultaneous determination of hexabromocyclododecane, tetrabromobisphenol A, and related compounds in sewage sludge and sediment samples from Ebro River Basin (Spain) [ J ]. Analytical and Bioanalytieal Chemistry, 2010, 397 (7) : 2817-2824. 被引量：1

引证文献5

二级引证文献20

毒理学杂志
2006年 第6期

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