摘要
采用PCR-RFLP方法检测钙通道α1亚基(Cav1．1)基因11外显子-1551位点T/C多态性与中国北方汉族男性甲亢性周期性麻痹(TPP)的相关性。TPP组TC+CC基因型和C基因频率显著高于甲亢(HT)组和健康对照(CON)组,CON组与HT组相比差异无统计学意义。Cav1．1基因-1551位点TC +CC基因型可能是中国北方汉族男性TPP患者的易感基因。
The association of polymorphisms of calcium channel α1 subunit （ Cavl. 1 ） gene （ - 1551T/C at exon 11 ） with thyrotoxic periodic paralysis （TPP） was investigated by PCR-RFLP. The distributions and frequencies of - 1551TC ＋ CC genotype and C allele in TPP group were significantly higher than those in hyperthyroidism （HT） and normal control （CON） groups. There was no statistic difference between HT and CON groups. Cavl. 1 gene - 1551TC ＋ CC genotype and allele may contribute to the development of TPP in male HAN population from North China.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2006年第6期576-577,共2页
Chinese Journal of Endocrinology and Metabolism
