摘要
目的探讨孕中期妇女(14～20周)外周血甲胎蛋白(AFP)和游离β绒毛膜促性腺激素(F-βhCG)在胎儿唐氏综合征产前筛查中的作用。方法采用酶联免疫吸附法检测孕妇血清AFP与F-βhCG浓度,结合孕妇年龄、孕周,利用配套软件计算胎儿患唐氏综合征的风险。结果筛查的789例孕妇中,唐氏综合征高危孕妇26例(阳性率3.3%);神经管缺损高危孕妇5例(阳性率0.6%)。结论血清标记物检测能显著降低需要进行创伤性产前诊断的孕妇比例,降低唐氏综合征患儿出生机率。
Objective To investigate the effect of screening for Down syndrome （DS） by detecting serum AFP and F-βhCG in pregnant women （14 to 20 weeks）. Methods Serum AFP and F-β hCG levels were measured by enzyme-linked immunosorbent assay （ELISA）, in combination with maternal age and gestatlonal age. Pregnant woman at risk for fetal DS were identified by analyses of special computer software. Results Among 789 cases pregnant woman, 26 cases （3.3%） were at high risk for DS. 5 cases （0. 6%） were found with fetuses at high risk of Neural Tube Defects. Conclusion Prenatal screening can reduce the need for invasive prenatal diagnosis, decressing the birth rate of DS.
出处
《福建医药杂志》
CAS
2006年第6期15-16,共2页
Fujian Medical Journal
