摘要
目的：明确前哨淋巴结（SLN）阳性乳腺癌中不同的临床病理特点，并确定非SLN（NSLN）发生转移的预测因素。方法：回顾分析726例成功确定了SLN的0～Ⅱ期乳腺癌病例，SLN阳性的185例患者接受腋窝淋巴结清除（ALND）。根据NSLN有无转移，将该185例分为两组，残余腋窝淋巴结有转移组（NSLN＋）81例，残余腋窝淋巴结无转移组（NSLN-）104例。结果：多变量分析显示，原发肿瘤较大（〉2．0cm）、淋巴管浸润、阳性SI，N较大（〉2mm）、所获得的SLN全部阳性4项均与NSLN阳性相关。在4项因素均存在的病例中，73％（30／41）存在NSLN阳性。结论：4项独立的预测因素与NSLN转移有关。
OBJECTIVE： To characterize the various clinicopathologic features in cases of breast cancer with positive sentinel lymph nodes （SLNs）, in order to determine factors that might help in predicting the involvement of non-SLNs. METHODS： A retrospective database review was performed of 726 breast cancer patients with stage 0- Ⅱ , in whom SLNs were successfully identified. One hundred eighty-five of these patients showed positive SLNs, and subsequently underwent axillary lymph node dissection （ALND）. These cases were divided into two groups based on the presence or absence of metastases in non-SLNs, positive non-SLNs （NSLN＋ ： 81 cases） and negative non-SLNs （NSLN-： 104 cases）. RESULTS： Multivariate analysis revealed that a larger size of the primary tumour （〉2.0 cm）, presence of lymphatic invasion, larger size of the largest SLN metastasis （〉2 mm）, and a 100% metastatic rate in SLNs （number of positive SLNs/number of harvested SLNs） were significantly associated with NSLNC. Among the cases in which all the four factors were present, 73% （30/41） were found to have NSLNC. CONCLUSIONS： Four independent predictors are in relation to non SLN metastasis.
出处
《中华肿瘤防治杂志》
CAS
2006年第19期1496-1498,共3页
Chinese Journal of Cancer Prevention and Treatment
