摘要
目的:探讨涎腺透明细胞癌(CCCs)生物学特性和组织来源。方法:收集8例涎腺透明细胞癌标本,采用免疫组化方法和文献回顾对涎腺透明细胞癌进行研究分析。结果:透明细胞癌EMA和CK8全阳性表达(8/8、100/100),Ck18和CK-HMW小部分阳性表达(各2/8、25/100),S-100仅1例阳性表达。SMA、Calpon in和P53无表达,bc l-2全阳性表达,PCNA阳性表达率为72.25%。结论:涎腺透明细胞癌是腺上皮性肿瘤,肿瘤细胞增殖活跃,是一种低度恶性肿瘤。
Objective： To study the origination and biologic features of clear cell carcinoma of salivary glands （CCCs）. Methods： 8 cases CCCs were indentified and studied by literature and immunohistochemistry, Results： Immunohistochemically, EMA and CK8 were positive in all cases. CK18 and CK -HMW were positive in 2 cases, respectively. S - 100 was positive in 1 case. Calponin, SMA and p53 were negative in all cases. The positive rate of PCNA were 72.25%. Conclusion： Clear cell carcinoma of salivary gland is adeno - epithelial neoplasms, with higher rate of proliferation. It is lower grade maglignance.
出处
《口腔医学研究》
CAS
CSCD
2006年第6期668-671,共4页
Journal of Oral Science Research
基金
南京医科大学附属口腔医院江苏省口腔医院人才引进科研启动基金(编号:KY2003001)
关键词
涎腺
透明细胞癌
免疫组织化学
临床病理
Salivary glands
Clear cell carcinoma
Immunohistochemistry
Clinico-pathology
