摘要
报道４例罕见的ＡＦＰ阳性结肠和直肠癌，此癌多见于中、老年男性患者，具有独特的病理形态与临床生物学行为，血清ＡＦＰ明显增高。病理组织形态特点是：除１例为单纯性腺癌外，另３例均见两种不同而又密切相关的腺癌区和肝样分化区。免疫组织化学染色，显示在肝样区的癌细胞浆内含有ＡＦＰ、ＡＡＴ和ＡＣＴ成份，而在腺癌区的癌细胞浆内则以ＣＥＡ成份为主。此癌高度恶性，由于ＡＦＰ的免疫抑制作用，常发生肝转移（３／４），所以预后不良。本组４例均死亡，术后平均生存１６．２５个月。综合文献与本组结果，作者认为此癌应列为结肠与直肠癌的一个特殊亚型。
cases of AFP-positive carcinoma of the colon and rectum were reported.These tumors occured primarily in the middle to old-aged men, had a special pathohistological and clinical biological behaviors,and showed a significantly high level of serum AFP,The pathohistological characteristics of these tumors were as follows: except one case was simple adenocarcinoma, the other three were composed of two diferent but closely related areas: hepatoid and adenocarcinomatous areas. Immunohistochemical staining demonstrated that the tumor cells in hepatoid foci contained some serum proteins, including AFP,AAT,ACT, and cells in adenocarcinomatous foci may contain some of the above proteins, but CEA was the main substance in cytoplasms of the tumor cells.The biological behavior of the tumor was highly malignant and the patients had a poor prognosis due to metastasis to liver by immunosuppressive effect of AFP,All 4 patients had died.The mean survival time after operation was 16. 25 months.Taking the literatures and results of this study into consideration,we think that the hepatoid adenocarcinoma is a special subtype of the colon- rectal adenocarcinoma.
出处
《实用癌症杂志》
1996年第4期247-249,共3页
The Practical Journal of Cancer
关键词
甲胎蛋白
结肠癌
直肠癌
免疫组织化学
肠肿瘤
Alpha-fetoprotein Colon-rectal carcinoma Hepatoid differentiation Immunohistochemistry
