摘要
急性白血病的复发与难治和白血病发生多药耐药（multidrugresistance，MDR）有关，发生MDR现象的主要机制是多药耐药基因（mdr；基因）的过度表达，mdr；基因的表达产物为定位于细胞膜上．分子量为170KDa的糖蛋白（Glycoproteins，P-170），为探讨P－170在复发难治性白血病中的表达及临床意义，用免疫组织化学ABC法检测了48例复发难治性白血病的P－170表达，其，阳性表达率为77．1％．结果表明：P－170在复发难治性白血病中有高度表达，本方法检测白血病MDR及对逆转白血病的MDR有一定的临床意义及指导意义．
The relapse and refractoriness of leukemia are associated with the occurrence of mul-tidrug resistance (MDR) whick is the result of mdrl gene expression and the excessive production ofP-170. The expression of P-170in 48 sases of relapsing and refractory leukemia was examined bymeans of immunocytoehemistry ABC method) and direct monoclonal antibodies JSB-1. The incidenceof P-1170 is up to 77. 1 %. The result showed that P-170 hase positive relation with relapsing and re-fractory leukemia and this mathod hase clinical significance in reversing the MDR of relapsing an-drefactory leukemia.
出处
《泸州医学院学报》
1996年第4期260-262,共3页
Journal of Luzhou Medical College
