摘要
前列腺癌(PCa)是一种重要的泌尿生殖系统恶性肿瘤,其发病率和死亡率有增长趋势。谷胱甘肽S-转移酶P1(GSTP1)属II相代谢酶,在致癌物的活化和解毒过程中起重要作用,其多态性与PCa的风险性可能有密切联系。检测GSTP1CpG岛超甲基化能可靠的区分PCa和良性前列腺增生(BPH),有可能成为诊断PCa的一个重要分子标志。现就GSTP1与PCa诊断及风险性之间的关系作一综述。
Prostate cancer（PCa） is an important genitourinary malignancy with increasing morbidity and mortality. Glutathione S-trans- ferase P1 （ GSTP1 ） , as a phrase-Ⅱ enzyme, has an important role in the activation and detoxification of carcinogens. There is a close association between GSTP1 gene polymorphisms and the risk of Pca. GSTP1CpG island hypermethylation can reliably distinguish Pca from benign prostatic hyperplasia（BPH） and promises to be an important molecular marker for the diagnosis of Pca. This paper summarizes the association of GSTP1 with the diagnosis and risk of Pca.
出处
《中华男科学杂志》
CAS
CSCD
2006年第12期1113-1115,共3页
National Journal of Andrology
