摘要
目的探讨尼莫地平联合氟西汀对脑卒中后患者抑郁状态的影响。方法将我院68例脑卒中后抑郁患者随机分为观察组36例和对照组32例,观察组患者给予尼莫地平+氟西汀,对照组患者单纯给予氟西汀,在治疗前和治疗后8周分别用汉密尔顿抑郁量表(Hamiltondepression,HAMD)、简易精神状态检查量表(MiniMentalStateEx-amination,MMSE)、临床神经功能缺损量表(Chinesestrokescale,CSS)、Barthel指数(ModifiedBarthelindex,MBI)评价两组患者的疗效。结果两组患者疗效间差异有显著性意义(P<0·05),观察组患者治疗前、后及两组患者治疗后HAMD、MMSE、CSS、MBI评分间差异有显著性意义(P<0·05);对照组患者治疗前、后HAMD、MMSE评分间差异有显著性意义(P<0·05)。结论尼莫地平联合氟西汀对脑卒中后抑郁有较好疗效,而且能够明显改善患者认知能力和神经功能,提高日常生活活动能力。
Objective To recover the effect of nimodipine on depressive state of post - stroke patients. Methods 68 post- stroke patients were randomly divided into the nimodipine combined fluoxetine group （36 cases） and the fluoxetine group （32 cases）, clinical progress was monitored with HAMD, MMSE, CSS and Barthel index before and after 8 weeks treatment. Results After 8 weeks treatment the total effective rate of depressive in the treatment group and control group were 81.6% and 56.25%, there was statistic difference between two groups （ P 〈 0. 05 ） ; in both of the two groups HAMD score were decreased, MMSE score were increased, there was statistic difference between two groups （ P 〈 0.05）. The Barthel index in nimodipine combined fluoxetine group were higher than fluoxetine group, the CCS score was lower than fluoxetine group, and there was statistic difference between two groups （ P 〈 0. 05）. Conclusion Nimodipine combined fluoxetine has higher effect to post - stroke patients who were depressed ; and it can improve the cognitive ability, nerves function and activity of daily living.
出处
《实用心脑肺血管病杂志》
2006年第10期799-800,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
尼莫地平
氟西汀
脑血管意外
抑郁
Nimodipine
Fluoxetine
Cerebrovascular accident
Depression
