摘要
目的：评价A型肉毒毒素对晚期脊髓损伤患者下肢痉挛性疼痛和反射性挛缩状态的治疗作用。方法：10例晚期脊髓损伤后痉挛状态患者,对痉挛肌肉进行A型肉毒毒素多点注射,记录治疗前及治疗后14d、30d、60d、90d时痉挛肌肉的改良Ashworth分级、痉挛性疼痛视觉模拟评分(VAS)、夜间12h内抽搐的发生率。结果：注射后14d所有被注射肌肉(100%)的改良Ashworth分级均明显下降(p＜0．01),这种肌肉张力的降低持续至少90d；注射后VAS、夜间12h内抽搐的频率均显著改善(p＜0．01)；未发现不良反应。结论：A型肉毒毒素可显著改善晚期脊髓损伤患者的痉挛状态、反射性抽搐和双下肢疼痛,安全而有效,明显减少患者的痛苦。
Objective：To investigate the effect of botulinum toxin type A （BTXA） on lower limb spasticity in late spinal injury patients. Methods： 10 late spinal injury patients who had severe spasticity received BTXA injection into muscles of the affected crura or into a controlled group. The severity of spasticity were evaluated by Modified Ashworth Scale（ MAS）, All patientsMAS stage were ≥grade Ⅱ ;the level of impairment pain were estimated by Visual analogue scale（VAS） ; the degree of twitch were recored from 8pm to 8am. All data were recorded and compared before and after 7,14,30,90 days of treatment. Resuits： All patients who received BTXA had significant reprovement of MAS （ p 〈 0.01 ）, the intervention of muscle tone reduction lasted at least for 90 days. Both the visual analogue scale and frequency of nights tic improved （ p 〈0.01 ）. There were no major adverse events associated with injection of BTXA. Conclusion：Intra muscular injection of BTXA is a safe and useful method in reducing spasticity,twitch and pain of the affected lower limb muscles in late spinal injury patients.
出处
《九江学院学报（自然科学版）》
CAS
2006年第4期43-45,共3页
Journal of Jiujiang University：Natural Science Edition
