摘要
对海洋来源具有抗肿瘤活性的真菌A-f-11中活性次级代谢产物进行了研究,采用活性追踪的方法从乙酸乙酯提取物中分离得到7个含吲哚基的二酮哌嗪类化合物,根据化合物的光谱特征和理化性质分别鉴定为cyclo-L-tryptophyl-L-proline(1),N-Prenyl-cyclo-L-tryptophyl-L-proline(2),tryprostatin B(3),dem ethoxyfum itrem orgin C(4),fum it remorgin C(5),cyclotrypros-tatins B(6)和fum itrem orgin B(7),其中化合物2为新天然产物。利用丽丝胺罗丹明法,对7个单体化合物的抗肿瘤活性进行了初步评价。
To investigate the antitumor secondary metabolites of marine-derived fungal A-f-11. Seven indolyl diketopiperazine compounds were isolated with bioassay-guided separation procedure. The structures of these compounds were determined through extensive analysis of 1D and 2D-NMR data. Their antitumor activities against K562 cell lines were preliminarily evaluated by the lissamine rhodamine B method. Compound 2 was a new natural product.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2006年第12期749-752,764,共5页
Chinese Journal of Antibiotics
基金
国家自然科学基金(No.30470196)
国家863计划基金(2003A624020)
山东省和青岛市自然科学基金(No.Z2001C01&04-2-JZ-81)
关键词
海洋来源真菌
吲哚二酮哌嗪
抗肿瘤活性
Marine-derived fungus
Indolyl diketopiperazine compounds
Antitumor activity
