摘要
目的观察GABAB受体激动剂-巴氯酚二次重复注射对大鼠血压的影响。方法对氨基甲酸乙酯麻醉的大鼠行巴氯酚二次重复腹腔注射,通过股动脉插管记录血压,比较两次注射后血压的变化。结果首次注入后血压由(113.2±8.3)mmHg显著升至(139.2±11.2)mmHg(P<0.05)并维持;60min后行第二次巴氯酚注射,血压却显著降至(120.3±20.4)mmHg,与首次注射前血压无显著性差异(P>0.05)。结论巴氯酚重复注射翻转了首次注射的升压效应,原因可能与受体内化有关。
Objective To study the effects of repeated administration of GABAB receptor agonist-Baclofen on mean blood pressure in rats and to probe into the mechanism, Methods Baclofen was administered twice intraperitoneally into urethane-anesthetized rats. Mean blood pressure （MBP） was measured through Maclab/8S by a catheter inserted into left femoral artery. Changes of MBP before and after first injection and after second injection were compared. Results First treatment with Baclofen produced a marked and prohinged increase in MBP, from 113.2 ± 8.3 mmHg to 139.2 ± 11.2 mmHg （P 〈0.05） and MBP maintained at the level of 139.7 ± 21.7 mmHg. The second injection was administered 60 minutes later after the first injection, and MBP decrease from 139.2 ± 11.2 mmHg to 120.3 ± 20.4 mmHg（ P 〈 0.05 ）. There was no significant difference between MBP before the first injection and that after the second injection （ P 〉 0.05）. Conclusion The effect of blood pressure elevation caused by the first administration of baelofen could be reversed by the second injection, whose cause might be the internalization of receptor.
出处
《杭州师范学院学报（医学版）》
CAS
2006年第5期301-303,共3页
Journal of Hangzhou Teachers College :Medical Edition
关键词
GABAB激动剂
巴氯酚
重复注射
血压
G ABAB agonist
baclofen
repeated injection
mean blood pressure
