摘要
目的研究晚期妊娠妇女血清及胎儿脐血中铁蛋白、转铁蛋白受体水平的变化并探讨其相关性。方法根据血红蛋白(Hb)水平的不同各选取30例孕足月妇女定为观察组(100g/L^110g/L)、正常组(≥110g/L)。采用双抗体夹心法和透射免疫比浊法分别测定母血和脐血铁蛋白、转铁蛋白受体水平。结果观察组母血铁蛋白、转铁蛋白受体水平分别为(12.28±1.84)μg/L和(4.18±0.82)mg/L,脐血铁蛋白、转铁蛋白受体水平分别为(163.47±36.27)μg/L和(8.71±1.02)mg/L,与正常组的差异有显著性(P<0.01);母血中铁蛋白、转铁蛋白受体水平呈负相关(P<0.01)。结论通过对母血、脐血铁蛋白、转铁蛋白受体的测定可以了解孕妇、胎儿体内的铁营养状态,早期发现铁缺乏;铁蛋白、转铁蛋白受体的负相关调节,使妊娠晚期补充铁剂的治疗更安全。
Objective： To study the serum ferritin （SF） and serum transferrin receptor （sTfR） changes and the correlativity with pregnant women and fetal at trimeter. Methods： All the 60 pregnant women at trimeter were divided into two groups according to the level of hemoglobulim （Hb）, A （ n = 30） ： 100g/L - 110g/L, B （ n = 30） ≥110g/L, used as control group. The SF of both mothers and babies were measured by using chemiluminescent immunoassay （CLIA）. sTfR of them were measured by immunoturbidimetric assay. Results： Mothers＇SF and sTfR level of group A was （ 12. 28 ±1.84） μg/L and （4. 18 ±0. 82） mg/L, babies＇SF and sTfR level of group A was （ 163.47 ± 36. 27 ） μg,/L and （ 8. 71 ±1.02 ） mg/L. There was significantly different between group A and group B （ P 〈 0. 01 ）. A negative correlation was found between SF and sTfR （ P 〈 0. 01 ） in pregnant women. Conclusion ： The iron concentration of pregnant women and fetal can be explored by detecting their SF and sTfR, so that we can diagnose iron deficiency （ID） at trimeter earlier. Receiving iron treatment is a safe method because the level of SF is associated with sTfR in pregnant women.
出处
《中国优生与遗传杂志》
2006年第12期40-41,共2页
Chinese Journal of Birth Health & Heredity
关键词
转铁蛋白受体
铁蛋白
妊娠
脐血
Transfen＇in receptor
Fen＇itin
Pregnant
Fetal blood
