摘要
目的探讨血浆内皮素(ET-1)对大鼠梗阻性黄疸肾损伤的作用,以及丹参对肾损伤的保护作用。方法将64只大鼠随机分为4组(每组16只):正常对照组(CN)、假手术对照组(SO)、梗阻性黄疸组(OJ)、丹参治疗组(OJ+SM)。分别于手术后7 d和14 d两个时段检测血浆ET-1,TB,DB,BUN,Cr水平,同时对肾脏行病理形态学观察。结果与CN组和SO组比较,OJ组大鼠血浆ET-1,TB,DB,BUN,Cr水平明显升高(P<0.01),同时伴有肾脏病理形态学的改变。丹参治疗可使血浆ET-1,TB,DB,BUN,Cr水平明显降低,与OJ组比较有显著性差异(P<0.01),肾组织形态学变化明显减轻。结论梗阻性黄疸时大鼠血浆ET-1明显升高,与BUN和Cr呈正相关;丹参通过降低血浆ET-1水平对梗阻性黄疸大鼠肾脏起保护作用。
Objective To study the effect of Salvia miltiorrhiza on the renal injury in obstructive jaundice rats. Methods 64 cases of rats were randomly divided into four groups： the control group（CN） ,sham operated group（SO） ,obstructive jaundice group （OJ） and obstructive jaundice salvia miltiorrhiza treatment group （OJ ＋ SM） , 16 cases in each. Plasma levels of endothelin-1 （ ET-1 ）, total bililubin （ TB）, direct bililubin （ DB）, ures nitrogen （BUN） and creatinine （Cr） were measured on the 7 th and 14th day after opreration. Renal histopathological changes were observed with light microscopy. Results In OJ group, the plasma levels of ET-1, TB, DB, BUN and Cr were higher than those in SO group（P 〈0.01 ）, the plasma levels of ET-1, TB, DB, Cr and BUN in OJ ＋ SM group were lower than those in OJ group（P 〈 0.01 ）, renal histopathologieal changes were improved. Conclusion Plasma ET - 1 level increases in Wistar rats with obstructive jaundice, there is a positive correlationship between ET-1 and BUN and Cr, salvia miltiorrhiza may have the function of ameliorating renal disfunction by reducing ET-1 level.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2006年第12期2489-2490,共2页
Lishizhen Medicine and Materia Medica Research
关键词
梗阻性黄疸
丹参
血浆内皮素
肾功能
Obstructive jaundice
Salvia miltiorrhiza
Endothelin-1
Renal functions
