摘要
目的观察心衰合剂对心肌梗死(myocardial infarction,MI)后心力衰竭(heart failure,HF)大鼠模型心功能、血浆血管紧张素Ⅱ(angiotensinⅡ,AngⅡ)、组织形态学改变的影响。方法MI后10d的HF大鼠动物模型被随机分为4组,分别给予双蒸水、卡托普利、心衰合剂高剂量和心衰合剂低剂量灌胃4周,观察心衰合剂对MI后HF大鼠心功能、AngⅡ的影响和对心脏重量/体重(heart weight/body weight ratio,HW/BW)和MI区左室壁变薄比的影响。结果治疗后心衰合剂组较模型组心功能改善,每搏输出量(stroke volume,SV)、心输出量(cardiac output,CO)和心脏指数(cardiac index,CI)都明显增高(P<0.05,P<0.01),血浆AngⅡ与模型组比较显著下降(P<0.01),HW/BW及MI区室壁变薄比与模型组比较亦有显著差异(P<0.05,P<0.01)。结论心衰合剂能够改善MI后HF大鼠的心功能,降低其血浆AngⅡ水平,对心室重构有一定的抑制作用。
Objective To observe the effects of Xinshuaiheji （XSHJ） on cardiac function, plasma angiotensin Ⅱ （AngⅡ） and histomorphology in rats with heart failure after acute myocardial infarction. Methods A model of heart failure （HF） induced by myocardial infarction （MI） in rats was made, 10 days after MI, rats were treated for 4 weeks with bidist Water, Captopril, high dosage of XSHJ, low dosage of XSHJ. The effects of Xinshuaiheji on cardiac function （stroke volume, SV, cardiac output, CO, cardiac index, CI ） and Angll were observed. We also observed and compared the changes of heart weight/body weight ratio （HW/BW）, ratio of ventricular wall thinning in MI. Results After treatment with XSHJ, the cardiac function （SV, CO, CI） of HF rats improved （P〈0.05, P〈0.01）, and the level of Angll lowered significantly than that of model group （P〈0.01）. HW/BW and ratio of ventricular wall thinning in MI differed significant between the XSHJ group and the model group （P〈0.05, P〈0.01）. Conclusion XSHJ could improve the cardiac function of HF rats after MI, decrease the level of Ang If, and showed certain inhibitory effects on the ventricular remodeling.
出处
《中国中医药信息杂志》
CAS
CSCD
2006年第12期28-30,共3页
Chinese Journal of Information on Traditional Chinese Medicine
基金
首都医学发展科研基金项目资助(2002-3)
