摘要
目的探讨前额叶眶部(OBF)和背外侧(DLF)损伤对风险决策认知加工的影响,验证OBF参与风险决策认知加工过程的假说。方法OBF损伤患者21例,DLF损伤患者19例以及健康对照组(HC)40名,采用风险决策任务,比较各组执行风险决策的能力。结果组内与奖赏后相比,惩罚后HC组的风险选择频率显著下降(分别为0.68±0.16和0.54±0.23,P<0.01),表现为惩罚后风险选择的抑制效应;DLF损伤组患者在惩罚后的风险选择频率亦有显著下降(分别为0.72±0.22和0.63±0.25,P<0.05);而OBF损伤组患者在惩罚后风险选择的抑制效应消失(分别为0.79±0.19和0.82±0.18,P>0.05)。与HC组比较,OBF损伤组患者在奖赏后和惩罚后的风险选择频率均显著升高(奖赏后分别为0.68±0.16和0.79±0.19,惩罚后分别为0.54±0.23和0.82±0.18;P<0.05),而DLF损伤组患者无显著变化(奖赏后分别为0.68±0.16和0.72±0.22,惩罚后分别为0.54±0.23和0.63±0.25;P>0.05)。结论OBF和DLF在人类的风险决策认知加工过程存在分离。OBF损伤后的患者追求高奖赏,惩罚后风险选择的抑制效应消失,而DLF损伤组患者的风险决策能力正常。OBF可能参与了奖赏/惩罚认知加工过程,是风险决策认知加工和处理的重要脑区。
Objective To investigate the influence of injury of prefrontal cortex on the risk-taking decision-making and to test the hypothesis that the orbitofrontal area is involved in the special network of risk-taking decision-making. Methods 47 patients with lesions in the prefrontal lobe, 21 in the orbitofrontal area （OBF） and 19 in the dorsolateral prefrontal cortex （DLF） , and 40 healthy controls （ HC group） were administered with a risk-taking task. Results The risky response rate after punishment of the HC group was 0.54 ± 0.23, significantly fewer than before punishment （ t = - 3.82, P 〈 0.01 ） , and the risky response rate after punishment of the DLF injury group was 0.68 ± 0.16, significantly fewer than before punishment too （ t = - 2.32, P 〈 0.05 ）. The risky response rate after reward of the patients with lesions in OBF areas was 0.79 ± 0.19, significantly higher than that of the HC group （0.68 ± 0.16, P 〈 0.05 ）, and the risky response rate after punishment of the patients with lesions in OBF areas was 0. 82 ± 0. 18, significantly higher than that of the HC group （ 0.54 ± 0.23, P 〈 0.05 ）. The risky response rates after reward and after punishment of the DLP group were 0.72 ± 0.22 and 0.63 ± 0.25 respectively, both not significantly different from those of the HC group （ both P 〉 0.05 ）. Conclusion The patients with lesions in the orbitofrontal area, not in the dorsolateral prefrontal cortex, have a specific deficit in risk-taking decision-making, i.e. an inhibition effect of punishment, reduced sensitivity to punishment but increased sensitivity to reward. The orbitofrontal areas play an important role in risk-taking decision-making processes.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2006年第45期3169-3172,共4页
National Medical Journal of China
基金
国家重点基础研究发展计划(973计划)基金资助项目(2005CB522800)
国家自然科学基金资助项目(30370479
30670706)
国家教育部归国留学人员科研启动基金资助项目([2003]14)
安徽省优秀青年科技基金资助项目(04043071)
安微省教育厅重点自然科学基金资助项目(2004kj192zd)
关键词
额叶前皮质
认知
风险决策
Prefrontal cortex
Cognition
Risk-taking
