摘要
目的:评价依帕司他对糖尿病患者心率变异性的影响。方法:收集患者93例,分为治疗组和对照组,治疗组患者接受依帕司他50mg,每日3次治疗,服用4周,运用24小时动态心电图检测所有患者在治疗前后心率变异性指标的变化,明确依帕司他治疗糖尿病心脏自主神经病变的疗效。结果:治疗组心率变异性各项指标治疗4周后较治疗前有显著提高,自主神经症状明显好转,与对照组比较有显著意义。结论:依帕司他治疗糖尿病心脏自主神经病变的疗效显著,可以改善患者心率变异性。
OBJECTIVE ： To evaluate the effect of epalrestat on heart rate variability （HRV） in diabetes. METHODS ： A total of 93 patients were assigned to receive 50mg epalrestat t. i. d for four weeks or placebo. The change of the HRV parameters of all patienes was detected using 24 - hour DCG （dynamic electrocardiogram）, and the efficacy of epalrestat on heart rate variability （HRV） in diabetics with cardiac autonmic neuropathy was investigated. RESULTS： In the treatment group, HRV parameters had a significant improvement four weeks after receiving treatment as against before treatment, cardiac autonmic neuropathy improved significantly, and there were significances as compared with control group. CONCLUSION： Epalrestat is effective for cardiac autonmic neuropathy in patients with diabetes and it can improve patients＇ HRV.
出处
《中国医院用药评价与分析》
2006年第5期274-276,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
江苏省卫生厅临床药学科研课题.编号P200412
关键词
依帕司他
糖尿病
心脏自主神经病变
心率变异性
hpalrestat
diabetes
cardiac autonmic ncuropathy
heart rate variability （HRV）
