摘要
用缺Ｓｅ缺Ｉ的克山病病区粮为基础，分别添加Ｓｅ或／和Ｉ的饲料喂养４组大鼠。测定了心肌组织Ｓｅ和Ｔ３水平，α－ＧＰＤ、ＩＤＩ、ＧＰｘ活力以及血浆Ｔ４、Ｔ３水平。结果发现，缺Ｉ使大鼠血浆Ｔ４显著下降，而缺Ｓｅ又使适Ｉ大鼠血浆Ｔ４水平增高。所有４组血浆Ｔ３水平波动幅度不大。心肌未能测出ＩＤＩ活性，心肌Ｓｅ含量因饲料加Ｓｅ而增高，但没有影响心肌Ｔ３水平。心肌α－ＧＰＤ活性缺Ｉ组明显低于加Ｉ组，并与血浆Ｔ４水平高度正相关，而与心肌ＧＰｘ活性关系不明显。研究提示，克山病病区粮引起的大鼠心肌低能量代谢特点与缺Ｉ或缺Ｉ引起的ＴＨ代谢异常有明显关系。
he effects of combinediodine and selenum deficiency(Se -I -),of single deficiency of these trace elements(Se +I -,Se -I +),and of no deficiency(Se +I +)on the α glycerophosphate dehydrogenase(α GPD)activity were compared in the rat hearts with relation to the thyroid hormone metabolism and GPx activity.No type I 5` deiodinase activity was measured in the four groups,and Se or/and I deficiency has no influence on triiodothyronine level in the rat hearts.There was strong relationship between α GPD activity and plasma thyroxin,but no between α GPDactivity and GPx activity in the hearts.The results indicate that I may be more important than Se in energy metabolism of myocardium,which can be considered as a new clue for the study on the etiology of Keshan disease in which endemic grains are deficient in both Se and I.
出处
《中国地方病学杂志》
CSCD
1996年第4期215-218,共4页
Chinese Jouranl of Endemiology
关键词
硒缺乏
碘缺乏
甲状腺激素
α-GPD
Selenium Iodine Thyroid hormone Glycerophosphate dehydrogenase Keshan disease
