摘要
目的:观察P33ING1b蛋白在口腔鳞状细胞癌中的表达情况,探讨其临床病理意义。方法:采用免疫组织化学ABC法,检测20例正常口腔黏膜和57例口腔鳞状细胞癌石蜡存档标本中P33ING1b的表达情况,并分析P33ING1b蛋白表达情况与患者临床病理特征的关系。结果:P33ING1b在大部分正常黏膜有表达,以细胞核为主,阳性表达率为90.00%,在口腔鳞状细胞癌中的表达以细胞核、细胞质共同着色为主,阳性表达率为24.56%,二者比较差异有显著性(P<0.05)。口腔鳞状细胞癌中淋巴结转移组阳性表达率为46.15%(12/26),淋巴结无转移组阳性表达率为6.45%(2/31),二者比较有显著性差异(P<0.05)。结论:P33ING1b蛋白在口腔鳞状细胞癌的发生发展中可能有重要的作用。其表达由细胞核转移到细胞质可能是主要机制;P33ING1b蛋白的表达与淋巴结转移有关,可以作为判断预后的一个潜在生物学标志。
Objective：To study the expression and clinical significance of P33^ING1b protein in oral squamous cell carcinoma（OSCC）. Methods： ABC imnmnohistochemical method was used to investigate the expression of P33^ING1b protein in paraffin blocks of 20 cases of normal oral mucosa and 57 of OSCC. The relationship between P33^ING1b expression and clinical data of the patients was analyzed. Results：In normal oral mucosa P33^ING1b protein was observed mostly in cell nuclear, but in OSCC in cell nuclear and cytoplasm. P33^ING1b was expressed in 90.00% of the cases of normal mucosa and 24, 56% of OSCC（ P 〈 0.05 ）. The positive rate of P33^ING1b protein expression was 46. 15% （12/26） in lymph node metastasis group and 6.45% （2/31） in non-metastasis group（ P 〈 0.05）. The P33^ING1b protein expression was not correlated witb gender, age, as well as tumor location （P 〉 0.05）. Conclusions：The P33^ING1b may play an important role in the tumorgenesis and development of OSCC,one of the mechanism most probably is the translocation of the protein from nuclear to cytoplasm.
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
2006年第6期811-813,共3页
Journal of Practical Stomatology
基金
河北省科技攻关计划资助项目(编号052761632)
