摘要
目的探讨心理护理干预对食管癌术后辅助化疗患者的免疫细胞功能是否存在积极的调节作用。方法将67例食管癌术后患者随机分为观察组和对照组,观察组(33例)进行长春地辛(VDS)方案辅助化疗及心理护理干预治疗,对照组(34例)仅进行VDS方案辅助化疗。测定护理干预前后两组患者的免疫细胞功能。结果观察组干预后CD4+活性较化疗前显著提高(P<0.05),而对照组干预后CD3+、CD4+、CD4+/CD8+及NK细胞活性显著降低(均P<0.05)。观察组干预后CD3+、CD4+、CD4+/CD8+及NK细胞活性显著高于对照组(均P<0.05)。结论心理护理干预对食管癌术后辅助化疗患者的免疫功能起着积极的调节作用。
Objective To explore whether the psychological nursing intervention therapy has the positive effect and adjustment on the immune function of the patients with esophageal carcinoma subject to adjuvant chemotherapy following operation. Methods Sixty-seven patients with esophageal carcinoma were randomly divided into 2 groups, observation group（n=33） received VDS adjuvant chemotherapy and psychological nursing intervention therapy, and control group （n=34） received VDS adjuvant chemotherapy alone. The immune function was detected before and after nursing intervention. Results The activity of CD4^＋ in the observation group after treatment were obviously increased as compared with those before intervention （P〈0.05）. The activity of CD3^＋ , CD4^＋ , CD4^＋ /CD8^＋ and NK cells in the control group after chemotherapy was obviously lower than those before chemotherapy （all P〈0.05）. The activity of CD3^＋ , CD4^＋ , CD4^ ＋/CD8^＋ and NK cells in observation group after intervention was higher than that in control group （all P〈0.05）. Conclusion The psychological nursing intervention therapy plays a positive role in immunological function of patients with esophagus carcinoma who receive chemotherapy.
关键词
食管癌
免疫细胞功能
心理护理干预
esophageal carcinoma immune cellular function psychological nursing intervention
