摘要
目的利用扩散张量纤维束成像(DTT)定量研究复发-好转型多发性硬化(RRMS)患者的皮质脊髓束分数各向异性(FA)值与正常志愿者之间的差异及其与扩展病残状态评分(EDSS)的相关性。方法对36例正常志愿者和64例RRMS患者进行扩散张量成像检查,重组出皮质脊髓束,计算出该纤维束的平均FA值,比较RRMS组与对照组之间是否存在差异,研究该指标与EDSS和锥体束评分的相关性。结果正常志愿者的皮质脊髓束FA值(男:0.501±0.026,女:0.493±0.024,左侧:0.500±0.031,右侧:0.494±0.024),无性别和侧别差异(P值均>0.05)。RRMS患者皮质脊髓束的FA值(0.472±0.037)明显低于对照组(0.497±0.028),差异有统计学意义(P<0.01)。脑型(0.469±0.038)与脊髓型(0.476±0.035)RRMS患者的皮质脊髓束FA值之间差异无统计学意义(P>0.05)。RRMS患者皮质脊髓束FA值与EDSS(平均3.0分)(r=-0.193,P<0.05)和锥体束评分(平均2.0分)(r=-0.218,P<0.05)存在弱相关性,其中,脑型患者的皮质脊髓束FA值与EDSS(平均3.1分)(r=-0.273,P<0.05)和锥体束评分(平均2.1分)(r=-0.268,P<0.05)的相关性较高,而在脊髓型患者的皮质脊髓束FA值与EDSS(平均2.8分)和锥体束评分(平均1.9分)均无显著相关性(r值分别为-0.080和-0.115,P值均>0.05)。结论RRMS患者皮质脊髓束的FA值存在明显异常,该指标可用作评价脑型RRMS患者的临床功能状态。
Objective To investigate whether the average fractional anisotropy （FA） of the corticospinal tracts is statistically different between patients with relapsing-remitting multiple sclerosis （RRMS） and normal volunteers by using diffusion tensor traetography （ DTT）, and to determine whether this index correlated with expanded disability status scale （EDSS） in RRMS patients. Methods Thirty-six volunteers and 64 patients with RRMS underwent diffusion tensor imaging. Then the corticospinal tracts were reconstructed, and the FA values of them were computed. The difference of FA of the corticospinal tracts between RRMS patients and normal volunteers was investigated, and the correlation of this index with EDSS and pyramidal score was also determined. Results There was no sex （male： 0. 501 ± 0. 026, female： 0. 493 ± 0. 024 ） and side （ left ： 0. 500 ± 0. 031, right ： 0. 494 ± 0. 024 ） differences of FA on eortieospinal tracts （ P 〉 0.05 ）. The average FA of the corticospinal tracts （ 0. 472 ± 0.037 ） of RRMS group was significantly lower than that of normal control group （0. 497 ±0. 028） （P 〈0. 001 ）. However, the average FA of cerebral type （0. 469 ±0. 038） of RRMS had no statistical difference with that （0. 476 ±0. 035） of spinal type （P 〉0. 05）. The average FA of the eortieospinal tracts correlated with EDSS （r = - 0. 193, P 〈 0. 05 ） and pyramidal score （ mean value = 2. 0） （ r = - 0. 218, P 〈 0. 05）. Among them, the FA of the corticospinal tracts of the cerebral type of RRMS correlated more with EDSS （ mean value = 3. 1 ） （r= -0.273,P〈0.05） and pyramidal score （mean value =2.1） （r= -0.268, P〈0.05）, but this correlation was not found in the spinal type （ P 〉 0. 05 ）. Conclusion The average FA of the corticospinal tracts of RRMS patients is significantly abnormal and this index may be suitable in evaluating the functional status of the cerebral type of RRMS patients.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2006年第11期1125-1128,共4页
Chinese Journal of Radiology
基金
北京市自然科学基金资助项目(7042026)
北京市优秀人才培养专项基金资助项目(20041D0501825)
关键词
多发性硬化
锥体束
磁共振成像
扩散
Multiple sclerosis
Pyramidal tracts
Magnetic resonance imaging
Diffusion
