摘要
本文采用瑞氏-姬姆萨染色法对50例急性淋巴细胞白血病缓解期病人及20例治疗前患者外周血中的凋亡淋巴细胞进行了观察。患者经化疗药物诱导治疗缓解后，外周血涂片中均可见到凋亡淋巴细胞；凋亡细胞的阳性率为4％～15％，平均7．63±4．82％。治疗前患者外周血仅1例查出凋亡淋巴细胞，且阳性率极低。与治疗前相比缓解期病人外周血凋亡细胞的出现率及阳性率均显著增加（P＜0．001）。表明恶性淋巴细胞化疗后部分细胞发生凋亡，凋亡细胞的出现可能与临床症状的缓解有关。文中还对凋亡淋巴细胞出现的凋亡小体、细胞膜、细胞浆和细胞核的各种形态学表现进行了讨论。
The apoptotic lymphocytes of the periphral blood in the 50 patients with catabasis of acute lymphocytic leukemia (ALL) and 20 non-catabasis of ALL were observed by WrightGiemsa stain technique. In the catabasis,all patients present apoptotic lymphocytes in periphral blood. The apoptotic lymphocytes were 4%～15% (7．63 ±4. 82%). Before the chemotherapy, among the 20 patients only one case had apoptotic lymphocytes, and their number was very low. In comparison with untreated patients, the incidence and positive rate of the apoptotic lymphocytes in periphral blood of the catabasis patients were all significantly high(P<0. 001),These results indicated that after chemotherapy the partial malignant lymphocytes developed apoptosis. The disappearance of clinical symptoms was probably related to the presentation of apoptotic lymphocytes. Apoptotic body and morphological changes of cell membrane,cytoplasm and cell nucleus were discussed in this paper.
出处
《洛阳医专学报》
1996年第3期145-147,共3页
Journal of Luoyang Medical College
关键词
急性
淋巴细胞
白血病
缓解期
细胞凋亡
acute lymphocytic leukemia
chemotherapy
catabasis
lymphocyte
apoptosis
