摘要
本工作采用核团内微量注射的方法，以甩尾反射潜伏期（ＴＦＬ）为痛阈指标，在浅麻状态下的大鼠上，对神经激肽Ａ（ＮＫＡ）在外侧网状核（ＬＲＮ）和中缝大核（ＮＲＭ）中的作用作了探讨。研究结果表明，ＮＫＡ（０．５μｇ／０．５μｌ）注入ＬＲＮ后的１０ｍｉｎ内大鼠ＴＦＬ明显延长（ｎ＝１２，Ｐ＜０．００１），同样剂量ＮＫＡ注入ＮＲＭ后的５ｍｉｎ内，ＴＦＬ也明显延长（ｎ＝１３，Ｐ＜０．００１），提示ＮＫＡ可能是ＬＲＮ和ＮＲＭ内参与痛觉的一种神经调质。
Using the microinjection technique, the analgesic effect of neurokinin A (NKA)microinjected into the lateral reticular nucleus (LRN) and nucleus raphe magnus(NRM) was investigated in lightly pentobar bital-anesthetized rats using tail flick laten cy (TFL) as an index. Microinjection of NKA (0. 5 μg/0. 5μl) into LRN significantlyincreased TFL lasting for 10 min (n= 12, P< 0. 001 ). Microinjection of the sameamount of NKA into NRM also produced evident increase in TFL for 5 min (n= 13, P< 0. 001 ). The results indicate that NKA modulates pain reaction in both LRN andNRM in rats.
出处
《生理学报》
CAS
CSCD
北大核心
1996年第5期493-496,共4页
Acta Physiologica Sinica
关键词
神经激肽A
外侧网状核
中缝大核
镇痛
neurokinin A
lateral reticular nucleus
nucleus raphe magnus
tail flick reflex
microinjection
analgesia
