摘要
目的探讨米多君对血管迷走性晕厥儿童的治疗效果。方法将2003-07—2004-12在北京大学第一医院儿科就诊的46例晕厥反复发作、直立倾斜试验(HUT)阳性的血管迷走性晕厥患儿,分为米多君组、美托洛尔组及基础治疗组。首先应用HUT评价患儿的治疗反应及调整药物,所有患儿随访6个月后,如没有晕厥的发作者则停药,并继续随访。进一步评价患儿晕厥复发情况及药物的不良反应。结果米多君组、美托洛尔组及基础治疗组3组患儿HUT转阴率分别为75·0%、65·0%及20·0%。米多君组及美托洛尔组患儿的HUT转阴率明显高于基础治疗组(P均<0·05),而给药治疗的两组患儿的HUT转阴率差异无显著性(P>0·05)。在随访过程中,米多君组及美托洛尔组晕厥复发率分别为22·2%及30·7%,而基础治疗组的晕厥复发率为80·0%,前两组晕厥复发率显著低于后组(P均<0·05)。前两组之间的复发率差异无显著性(P>0·05)。结论米多君可有效治疗血管迷走性晕厥儿童。
Objective To determine whether midodrine hydrochloride therapy could prevent vasovagal syncope （ VVS ） in pediatric patients. Methods Forty-six children with recurrent syncope were included in the study. They were assigned into 3 groups. Midodrine group consisted of children who were administered with midodrine hydrochloride as the first-line therapy in addition to the conventional therapy. Metoprolol group consisted of patients who were administered with metoprolol as the first-line therapy based on the conventional therapy. Conventional therapy group included patients who were only given conventional therapy. Repeated head-up tilt test （HUT） and a follow-up at least for 6 months were conducted. Results The HUT-based effective rate was 75.00% for children treated with midodrine ,65.00% for children with meto- prolol,and 20. 00% for children with conventional therapy. It was significantly higher in cases of midodrine group and metoprolol group than that of conventional therapy group. However,there was no significant difference in the HUT-based effective rate between patients in midodrine group and metoprolol group （ P 〉 0. 05）. During the follow-up period, the recurrence rate of syncope for children in midodrine group and metoprolol group was significantly lower than that of conventional therapy group （ P 〈0. 05 ,respectively）. However,there was no significant difference in the recurrence rate of syncope between children in midodrine group and metoprolol group （ P 〉 0. 05 ）. Conelusion Midodrine is as effective as metoprolol in the treatment of VVS in children. Few side effects were observed in the present experiment.
出处
《中国实用儿科杂志》
CSCD
北大核心
2006年第11期826-828,共3页
Chinese Journal of Practical Pediatrics
基金
国家十五攻关计划(2004BA720A10)
首都医学发展基金资助(2002-3037)
