摘要
以甲壳素为原料,95%乙醇为反应介质,一锅连续法制备羧甲基壳聚糖的适宜条件为:m(甲壳素)∶m(氢氧化钠)∶m(一氯乙酸)=1∶2.5~3.5∶3~4,脱乙酰化反应温度90℃~100℃;羧甲基化反应温度40℃~50℃,反应时间3 h^4 h,羧甲基壳聚糖产率可达115%(以甲壳素计),羧化度为1.16,4%水溶液的黏度为1662 m Pa.s。该法用碱量小,反应时间短,用水少,无废液排放,顺应环保要求而且产品黏度高。收率大,可降低其生产成本。
The preparation of carboxymethylchitosan by a one-pot continuous method was studied from chitin and 95% alcohol as a solvent. The optimum conditions are ： the mass ratio of chitin and NaOH to monochloroacetic acid is 1：2.5～3.5：3～4; temperature of deacetylation reaction for 90 ℃～100℃ ; temperature of carboxymethylation reaction for 40 ℃～50 ℃ and reaction time for three hours. The yield of carboxylmethylchitosan is 115%（hased on chitin）. The praduction processes high viscosity（viscosity of 4% aqueous solution for 1660 mPa·s）, high degree of substitution （SD for 1.16）, and low cost. This continuous preparative procedure can significantly reduced consumption of NaOH, reaction time and washing water.
出处
《高分子材料科学与工程》
EI
CAS
CSCD
北大核心
2006年第6期213-216,共4页
Polymer Materials Science & Engineering
基金
国家"973"计划资助项目(2003CB615700)
中国发明专利(专利号:200410036117.1)
关键词
羧甲基壳聚糖
甲壳索
乙醇
连续
carboxymethylchitosan
chitin
alcohol
continuous method
