摘要
目的：研究必需氨基酸蛋氨酸对大鼠胚胎神经管发育的影响。方法：大鼠体外全胚胎培养。结果：９．５ｄ大鼠胚胎在小牛血清中培养４８ｈ，观察到其发育明显落后于正常大鼠血清组，神经管严重未闭，添加了蛋氨酸的小牛血清（终浓度为２５．４４ｍｇ／Ｌ）中，胚胎发育仍现迟缓，但神经管闭合。结论：小牛血清中增补蛋氨酸有促进大鼠胚胎神经管闭合的作用。
Objective:To study the effect of methionine on neural tube closure of rat embryos. Methods:whole embryo culture. Results: embryos cultured in cow serum have open neural tubes after 48 h while those cultured with methionine supplementation have normal neural tube closure. Conclusion:Methion-ine supplementation to cow serum promotes the neural tube closure of cultured rat embryos.
出处
《北京医科大学学报》
CSCD
1996年第5期347-349,共3页
Journal of Peking University(Health Sciences)
关键词
蛋氨酸
神经管缺损
胎儿
Methionine/pharmacal:Neural tube defects/prev
Embryo/growth
