摘要
目的探讨雌激素受体(ER)、孕激素受体(PR)、生长因子受体(HER-2)、P-糖蛋白(P-gp)和谷胱甘肽-S-转移酶(GST-π)在乳腺癌中的表达与临床意义。方法应用免疫组织化学技术,检测85例乳腺癌患者中ER、PR、HER-2和P-gp、GST-π多药耐药的表达。结果85例乳腺癌患者中ER阳性率为52%,PR阳性率为51%,HER-2阴性率为54%,P-gp检测为(-)^(+)占85%,GST-π检测为(-)^(+)占69%,与乳腺癌临床化疗有相关性。结论ER、PR、HER-2、P-gp联合表达与乳腺癌化疗密切相关,检测ER、PR、HER-2、P-gp和GST-π对乳腺癌化疗方案的制定具有重要的意义。
Objective To discuss estrogen receptor（ER）, progesterone receptor（PR）, neu oncoprotein（HER- 2）, P-glycoprotein（P-gp） and glatathione S-transferase pi（GST-π） in the carcinoma of breast give voice to and clinical significance. Methods The expressions of estrogen receptor, progesterone receptor, neu oncoprotein, P-glycoprorein and glatathione S-transferase pi manifold medicine were determined by immunity histochemistry technology in 85 cases of breast carcinoma. Results The 85 cases estrogen receptor masculine quotiety became 52 % ,progesterone receptor masculine quotiety became 51% , neu oncoprotein shadow quotiety became 54 %, P-glycoprotein examine became （ - ） - （ ＋ ） 85 % and glatathione S-transferase pi examine became （ - ） - （ ＋ ） 69 % give voice to of masculine sign in the carcinoma of breast and clinical warfare had pertinence. Conclusion The estrogen receptor, proges- terone ,eceptor,neu oncoprotein,P-glycoprotein and glatathione S-transferase pi unite give voice to and of the carcinoma of breast warfare osculation pertinence. Jerque ER, PR, HER-2, P-gp and GST-π have important significance in instituting chems program of breast carcinoma.
出处
《中国基层医药》
CAS
2006年第10期1629-1631,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
受体
雌激素
受体
生长因子
乳腺肿瘤
Receptors, estrogen
Receptors, growth factor
Breast neoplasms
