摘要
对２３例嗅神经母细胞的治疗经验作回顾性分析．男１２例，女１１例．中位年龄２７岁．平均病程１６．８月。主要症状为鼻塞、涕血和嗅觉减退．生存率采用Ｋａｐｌａｎ－Ｍｅｉｅｒ方法进行分析，总的３年、５年生存率分别为６０％、４８．８％．男性患者及３０岁以下者预后较好。根据Ｋａｄｉｓｈ分类法，Ａ、Ｂ、Ｃ期的５年生存率分别为８５．７％、３４％、和２８．６％．根治性手术组、放疗组和手术加术后放疗组的５年生存率分别为３３．３％、４２．８％和６０％。由于本清对放疗有中度敏感性，我们认为本病的治疗应是根治性手术加术后放疗为佳．化疗对部分病人有一定的疗效．本文还结合文献讨论了本病的起源和诊断等问题．
A retrospective analysis of 23 patients with olfacfory neuroblactoma treated at tumour hospital,Sun Yatsen of medical science was conducted.There were 12 males and 11 Females.The median of age was 27 years.A mean period of the illness history was 16. 8 months.The most common symptoms were unilateral nasal obstruction,epistaxis and anosmia.KaplanMeier was used for survial analysis.The tofal 3-,5-year survival rates were 60%,48.8%,respectively.Prognosis was favorable in the male and the patients below 30 years.According to the staging system proposed by Kadish et al,the 5-year survival rates for stages A,B,C were 87%,34% and 28.6%,respectively.The 5-year survival rates for surgery,radiotherapy and combination of surgery and radiotherapy were 33.3%,42.8% and 60%,respectively.Because of the middle radiosensitiveness of the tumour,we recommend combined therapy with surgery and radiotherapy as optimal treatment.Combination chemotherapy had a beneficial response for some patients.The genesis and diagnosis of olfactory neuroblastoma was discussed.
出处
《伤残医学杂志》
1996年第3期30-31,共2页
Medical Journal of Trauma and Disability
关键词
嗅觉减退
鼻塞
涕血
嗅神经母细胞瘤
Olfactory neuroblastoma Anosmia Nasal obstruction Epistaxis
