摘要
目的：观察替尼泊甙和顺铂联合脑部放射治疗肺癌脑转移患者的疗效、不良反应和生存率。方法：替尼泊甙100mg，第1天到第3天；顺铂40mg，第1天到第3天，21d为1个周期。脑部放疗于第1个周期化疗开始后第5天开始，DT（1．8～2．0）Gy／次，1次／d，5次／周，单个病灶者全颅放疗DT30Gy后缩野追加至DT50Gy，多发转移灶者给予全颅放疗DT45Gy。结果：治疗后89％患者神经系统症状改善，对脑转移灶的客观有效率为68．3％（28／41），对肺原发灶的有效率为39．O％（16／41），主要不良反应为骨髓抑制和脱发，中位生存期9．8个月，1a生存率36．6％（15／41）。结论：同步放化疗治疗肺癌脑转移患者有效率和生存率均较高，且患者耐受性好。
Objective To investigate the therapeutic effect, toxicity, and survival of concurren tradiotherapy combined with DDP, and Vm-26 in lung cancer patients with brain metastases. Methods Vm-26 100rag ivdrip d1-d3 ; DDP 40mgivdrip d1-d3, every21d. Whole Brain radiotherapy was administered on day 5 of the firstcourse of chemotherapy by using60Co at a dose of DT 1.8 Gy/d-2.0 Gy/d Given in 5 fractions per week. Patients with1-2 brain lesions received Whole Brain radiotherapy at a dose of DT 30 Gy and then small field to a total dose of DT 50 Gy. Patients with more than 2 brain lesions of received Whole Brain radiotherapy at a total dose of DT 45 Gy. Results The treatment improved neurological symptoms in 89 % of the patients. The response rates to brain lesions and primary lesions were 68.3 % （28/ 41） and 39%（16/41）, respectively. The median survival time（MST） was 9.8 months; the 1-year survival rates was 36.6% （15/41）. The major toxicities were marrow suppression and alopecia. Oonclusion Concurrent radiochemotherapy can be safely preformed for the patients with brain metastases from lung cancer with a remarkable response rate and encouraging survival duration.
出处
《实用医技杂志》
2006年第20期3631-3632,共2页
Journal of Practical Medical Techniques
关键词
肺肿瘤
放射治疗
药物治疗
脑肿瘤
肿瘤转移
Lung neoplasms
Radiotherapy
Chemotherapy
Brain neoplasms
Neoplasmsmetastasis
