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应重视在高血压患者中开展原发性醛固酮增多症的筛查、确诊和分型定位检查 被引量:8

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摘要 自1955年Conn等报道首例原发性醛固酮增多症(简称原醛)患者以后的30多年中,原醛一直被认为是一种少见疾病,在高血压人群中原醛患病率不到1%。1981年Hiramatsu等首次采用血浆醛固酮/血浆肾素活性比值(ARR)作为原醛筛查指标,在348例未经选择的高血压患者中发现9例(2.6%)醛固酮腺瘤(APA)患者。从20世纪90年代起,国外普遍采用ARR作为原醛筛查指标,目前达成以下共识:原醛不是少见病,多数报道原醛占高血压患者的5%-15%。低血钾不是原醛必须具备的特征,在确诊的原醛患者中,低血钾发生率仅为9%-37%。澳大利亚Princess Alexandra医院高血压科自1991年起对所有高血压就诊患者进行ARR测定,使原醛的检出率提高了10倍,肾上腺腺瘤手术数增加了4倍。
作者 朱鼎良
出处 《中华心血管病杂志》 CAS CSCD 北大核心 2006年第10期865-867,共3页 Chinese Journal of Cardiology
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参考文献16

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