摘要
目的探讨双倍剂量科素亚治疗慢性肾炎肾性高血压的临床疗效和安全性。方法将50例肾性高血压患者分为科素亚单倍剂量组和科素亚双倍剂量组,分别应用科素亚50mg和100mg治疗12周,观察两组患者治疗前后血压、24小时尿蛋白定量、肝肾功能、血脂的变化和不良反应。结果两组患者的血压、24小时尿蛋白定量和尿酸水平均有显著性下降(P<0.05),而血肌酐、血钾、肝功能无显著变化(P>0.05);与单倍剂量科素亚治疗组比较,双倍剂量组患者治疗后24小时尿蛋白定量显著下降(P<0.05)。结论两组剂量科素亚治疗肾性高血压均有效,具有良好的安全性,但双倍剂量较单倍剂量科素亚对肾脏的保护作用更好。
Objective To investigate the clinical effect and safety of double dosage Losartan on renal hypertension patients with chronic glomerulonephritis. Methods 50 patients with renal hypertension were divided into signal dosage group （ Losartan 50mg qd ） and double dosage group （ Losartan 100 mg qd ） for 12 weeks, blood pressure, proteinuria in 24 hours,liver function, renal function and serum lipid were detected before and after 12 weeks. Results After treated with Losarsan, blood pressure,24h proteinuria and serum uric acid （UA） were decreased significantly （P 〈 0.05 ）in two groups, but sCr, serum kalium and liver function were not changed significantly （P 〉0.05） ;comparing with the signal dosage group,24h proteinuria in double dosage group was decreased significantly （P 〈 0.05）. Conclusion Treatment of renal hypertension with signal dosage and double dosage Losartan were effective and safe. Comparing to signal dosage losartan. 100mg losartan is more helpful to renal diseases.
出处
《临床内科杂志》
CAS
2006年第11期728-730,共3页
Journal of Clinical Internal Medicine
基金
上海市卫生局重点攻关课题(2003ZD001)
上海市医苑新星基金(02XX46)资助
关键词
科素亚
慢性肾小球肾炎
肾性高血压
双倍剂量
治疗
Losartan
Chronic glomerulonephritis
Renal hypertension
Double dosage
Therapy
