摘要
目的观察不同背景量舒芬太尼用于术后患者静脉自控镇痛的镇痛效果与不良反应。方法将60例择期全麻下行上腹部或开胸手术的患者随机分为3组,每组20例,分别使用背景量为0.001μg.kg-1.m in-1(S1组);0.000 5μg.kg-1.m in-1(S2组);0μg.kg-1.m in-1(S3组)的舒芬太尼,分别在术后6,24及48 h记录患者的视觉模拟法(VAS)评分,包括静息状态和运动状态,用药量、其他镇痛药的使用情况、不良反应发生情况及各项生命体征。结果S1组在静息状态下的VAS评分与S2组的静息评分相当(P>0.05),低于S3组(P<0.05)。S1组在运动状态下的VAS评分低于S2组(P<0.05)及S3组(P<0.01),恶心呕吐发生率S3<S1<S2,其他生命体征差异无显著性。满意度S1>S2>S3。结论术后患者静脉自控镇痛选择背景量为0.001 mg.kg-1.m in-1镇痛效果最好,恶心呕吐的发生率居中,患者使用的满意度最高,值得临床推广。
Objective To observe the analgesic effect and the side-effect of sufentanil with different basal volumes used for PCIA. Methods Sixty ASA Ⅰ -Ⅱ patients （32 male,28 female） aged 20-70 year weighing 45-98 kg undergoing elective thoracal or abdominal surgery under general anesthesia were separated into three groups randomly receiving PCIA with sufentanil 0.001 μg · kg^-1 μ min^-1（S1,n =20） ,0.000 5 μg· kg^-1 μ· min^-1 （S2,n =20） , 0 μg · kg^-1 · min^-1 （S3,n =20）. PCA 1 mL （ sufentanil 2 μg · mL^-1 ） was used in three groups with a 5 min lock-time through patient-controlled analgesia device Visual analogue scale （VAS） scores in quiet and cough, cumulative volumes of the intravenous drugs, vital signs including SPO2, HR, RR, and side-effect including sedation scores, nausea, vomit, pruritus and other analgesics were assessed after 6, 24 and 48 h of postoperative analgesia. Results VAS scores decreased when the basal volumes of sufentanil increased. VAS scores of group S1 were similar to group S2 （P 〉 0.05 ） , lower than group $3 （P 〈0.05 ） in quiet , were lower than group $2（ P 〈 0.05 ） and group S3（P 〈0.01 ） on movement. The rate of nausea in group S1 were lower than S2. Vital signs including SPO2 ,HR ,RR were in the normal range. Conclusion Sufentanil 0.001 μg · kg^1-· min^-1 can provide satisfying analgesia without increasing the side-effect .
出处
《医药导报》
CAS
2006年第11期1152-1154,共3页
Herald of Medicine
