摘要
目的探讨腹腔镜手术中二氧化碳(CO2)气腹对兔动脉粥样硬化心肌收缩力的影响及其机制。方法将72只日本大耳白兔随机分为两组:正常组(组A)和动脉粥样硬化组(组B)。按实验设计的气腹压力不同将A组动物进一步分为三个亚组:A1(免气腹对照组)、A2(10mmHg气腹120min)、A3(15mmHg气腹120min);B组亦分为三个亚组:B1(0mmHg气腹120min)、B2(10mmHg气腹120min)、B3(15mmHg的气腹120min)。按实验分组设计建立CO2气腹,采用多导生理仪监测动物左室内压最大上升速度(+DP/DTmax)和心室内压最大下降速度(-DP/DTmax)的变化,采取动脉血标本分析血气指标变化。结果建立气腹后30min,B3组+DP/DTmax、-DP/DTmax显著降低(P<0.05),而且较A3组更为显著;pH降低,PaCO2升高。在建立气腹120min,B3组所有指标进一步受到损害,而A3组不再有显著的变化。结论CO2气腹可降低兔术中心肌舒缩功能,而且动脉粥样硬化兔对高压力、长时间CO2气腹的耐受性比正常兔差。
Objective The aim of this study was to evaluate the effect of carbon dioxide pneumoperitoneum on the diastolic and systolic function of left ventricular in atherosclerosis rabbits. Methods 72 Japan white rabbits were randomized into 2 main groups： nonatherosclerosis （group A） and atherosclerosis （group B ）. After initial preparation and monitoring, each group was divided according to the degree of pneumoperitoneum. The nonatherosclerosis subgroups were A1, gasless （control group ）, A2, 10 mm Hg, A3, 15 nun Hg. The atherosclerosis subgroups were B1, gasless （control group ）, B2, and B3 with pneumoperitoneum at 10 mm Hg, 15 mm Hg for 120 min, respectively. Left ventricular ±DP/DT max were monitored continuously using polygraph system.Blood samples were obtained for arterial blood gases analyses. Results With 15 mm Hg CO2 pneumoperitoneum for 30 min, the＋DP/DTmax,-DP/DTmax in group B3 decreased significantly compared to baseline values, and were lower than those in all other groups at the same time point, pH decreased, while pCO2 increased. At 120 min, all values were further depressed in group B3, but not in group A3. Conclusion Higher-pressure and longer duration of CO2 pneumoperitoneum in atherosclerosis rabbits decreases the diastolic and systolic function of left ventricular.
出处
《中国心血管病研究》
CAS
2006年第11期848-851,共4页
Chinese Journal of Cardiovascular Research
关键词
气腹
动脉硬化
心肌收缩
血气分析
Pneumoperitoneum
Atheriosclerosis
Myocardial contraction
Blood gas analysis
