摘要
目的 观察肾集合管癌的临床病理特点.方法 调研病人临床资料,记录肿瘤大体、光镜及电镜下的形态,运用免疫组化检测CK34βE12、CK19、CK13、vimentin、S-100、CEA、Ki-67,并对4例患者进行随访.结果 4例肿瘤主体位于肾髓质,其中2例累及肾周脂肪囊;1例大部分突入肾盂（镜下肿瘤表面尚被覆移行上皮黏膜）;肾集合管癌细胞中等大小,部分胞质嗜酸,部分透亮,部分核呈空泡状,有小核仁,组织结构呈小的腺管状、实片状、乳头状,癌组织间纤维组织增生明显,其中2例伴片状坏死,1例伴大量中性粒细胞浸润;瘤细胞CK34βE12和CK19（＋）,CK13、vimentin、S-100（-）、Ki-67 10%～15%;2例患者术后死亡,2例存活.结论 肾集合管癌是具有特殊形态和免疫表型、预后较差的肿瘤,应通过组织学改变和免疫组化等方法与其他胃肿瘤鉴别.
Objective To observe the the clinicopathologic features of collecting duct carcinoma of the kidney. Methods The clinical data of patients were reviewed and the gross, light microscopic morphology of tumors were noted down. Immunohistechemical assays of CK34βE12, CK19, CK13, vimentin, S-100 and Ki67 were used to stain the tissues of tumors. Follow-up was carried out for all the patients. Results Four tumors mainly located in the medullary of kidney. There were various patterns including gland-like, solid and papillary pattern with desmoplastic reaction in the four tumors. The tumor cells were positive for CK34βE12, and CK19, the positive rate of Ki67 was more than 15%, but negative for vimentin and S-100. Conclusion Collecting duct carcinoma has special morphology and immunotype tumor with very poor prognosis. This tumor should be differentiated from other renal epithelial tumors on the basis of histologic changes and adjunct assays.
出处
《诊断病理学杂志》
CSCD
2006年第5期371-372,I0016,共3页
Chinese Journal of Diagnostic Pathology
关键词
肾
肿瘤
集合管癌
Kidney
Neoplasm
Collecting duct carcinoma
