摘要
目的:探讨以头孢他美与特戊酸碘甲酯为原料,合成头孢他美特戊酰氧甲酯路线的可行性,研究原料配比、催化剂、反应温度、反应时间等因素对实验结果的影响。方法:在极性非质子性溶剂N,N-二甲基甲酰胺溶液中,在一定反应温度和反应时间下,用碱作催化剂,以头孢他美与特戊酸碘甲酯为原料,合成头孢他美特戊酰氧甲酯,并优化反应条件。结果:在极性非质子性溶剂N,N-二甲基甲酰胺溶液中,在三乙胺催化下,反应温度20～23℃,以头孢他美与特戊酸碘甲酯为原料,合成头孢他美特戊酰氧甲酯的路线是最佳合成路线,收率可达84%。结论:原料配比、碱、反应温度、反应时间等因素对产品质量、色泽、收率有很大影响。
Objective： To investigate the synthesis route of cefetamet pivoxil from iodomethyl pivalate and cefetamet and affecting factors. Methods： Cefetamet pivoxil was synthesized from iodomethyl pivalate and cefetamet in the N, N-dimethylformamide solution, with the presence of base and at 0 -40 ℃. Results： Optimum conditions for cefetamet pivoxil synthesis was summarized that the ratio of iodomethyl pivalate to cefetamet was 0.5：1 in the N ,N-dimethylformamide solution, with the presence of Et3N, and the reaction temperature was 20 -23 ℃. The objective compound was obtained by 84% of the total yield. Conclusion： Quality, color and yield of cefetamet pivoxil are affected by material ratio, catalyst, temperature and reaction time.
出处
《贵阳医学院学报》
CAS
2006年第5期403-405,共3页
Journal of Guiyang Medical College
关键词
抗生素类
温度
时间
碱类
特戊酸碘甲酯
头孢他美酯
antibiotics
temperature
time
alkalies
iodometyl pivalate
cefetamet pivoxil
