摘要
目的：观察健脾补肾方治疗慢性丙型肝炎的临床疗效。方法：将40例患者随机分为2组。治疗组20例,以健脾补肾方(由太子参、茯苓、三七、赤芍、丹参、杜仲、珍珠草、田基黄、菟丝子、五爪龙、郁金、何首鸟等组成)治疗。对照组20例,使用干扰素(因特芬)治疗。2组疗程均为6月。观察治疗前后肝功能、肝纤维化指标、丙型肝炎病毒RNA定量(HCV- RNA)等指标的恢复情况。结果：治疗后2组谷丙转氨酶(ALT)、谷草转氨酶(AST)均明显降低,与治疗前比较,差异均有非常显著性意义(P＜0．01)。治疗后2组Ⅲ型前胶原(PCⅢ)、透明质酸(HA)、层粘连蛋白(LN)均明显降低,与治疗前比较,差异均有显著性意义(P＜0．05)；其中治疗组HA降低尤为明显,与对照组比较,差异有显著性意义(P＜0．05)。治疗后HCV-RNA转阴率治疗组(15%)与对照组(55%)比较,差异有非常显著性意义(P＜0．01)。结论：健脾补肾方治疗慢性丙型肝炎有恢复肝功能的作用,而且在抗纤维化方面具有优势,但对降低HCV-RNA定量及转阴疗效不及因特芬。
Objective:To observe the clinical effect of Jianpi Bushen Fang(JBF) for chronic hepatitis C (CHC).Methods:40 cases were allo- cated to 2 groups randomly.The treatment group (20 cases) was treated by JBF (composed of Radix Pseudostellariae,Poria,Radix Notoginseng, Radix Paeoniae Rubra,Radix Salviae Miltiorrhizae,Cortex Eucommiae, Herba Phyllanthi Urinariae,Herba Hyperici Japonici,Semen Cuscutae, Folium Ipomoeae Cairicae,Radix Curcumae,Radix Polygoni Multiflori Preparata,etc.).The control group (20 cases) was treated by interferon. 6 months constituted the course of treatment.The liver function,parame- ters of liver fibrosis and quantitative test of HCV-RNA were observed be- fore and after treatment.Results:After treatment,the ALT and AST of both groups were markedly decreased (P＜0.01).The precollagenⅢ, hyaluronic acid (HA) and laminin of both groups were markedly decreased (P＜0.05),HA of treatment group was decreased obviously than control group (P＜0.05).After treatment,the HCV-RNA negative rate was 15% and 55% in treatment group and control group respectively (P＜0.05).Conclusion:JBF can restore liver function in CHC and has an ad- vantage in counteracting fibrosis
出处
《新中医》
CAS
北大核心
2006年第11期33-35,共3页
New Chinese Medicine
