摘要
目的用壳聚糖和海藻酸钠为原料,制备干扰素-tau微囊,希望开发成为一种口服干扰素制剂。方法使用注射器手工滴制的方法,在滴加过程中,速度和距离是影响囊形的主要因素。结果壳聚糖-海藻酸钠微囊法应用于干扰素-tau药物的包封,其制备简单快速,干扰素-tau包封率很高,并且具有肠溶缓释作用。结论壳聚糖-海藻酸钠微囊有望用作干扰素-tau或其它肽类药物的口服制剂。
Objective The microcapsules were prepared by using chitosan and sodium alginate as wall materials, and the controlled-release microcapsulas of interferon tau were hoped to be develop an oral interferon preparation. Methods The microcapsules were prepared by using syringe hand-made drop. In the process of dropping, speed and distance were the major factors which influence the form of microcapsules. Results Chitosan-alginate microcapsules which was prepared simple and fast had high encapsulation rate and extended-release effect in intestine. Conclusion Chitosan-alginate microcapsules have the potential to be used to prepare interferon tau and other protein medicines.
出处
《中国海洋药物》
CAS
CSCD
2006年第5期28-30,共3页
Chinese Journal of Marine Drugs
基金
山东省科技厅资助项目(No.0310501010)
关键词
干扰素-tau
壳聚糖
海藻酸钠
包封率
微囊
interferon tau, chitosan, sodium alginate
encapsulation rate
microcapsule
