摘要
高原鼢鼠是终生生活于地下封闭洞道中的一种啮齿动物。为了探讨高原鼢鼠对低氧和高二氧化碳环境的适应机制,对春、夏和秋三季高原鼢鼠血液生理指标以及心肌和骨骼肌肌红蛋白含量进行了测定。春、夏和秋季高原鼢鼠动脉血和静脉血pH值分别为7.44±0.09、7.44±0.05、7.51±0.07和7.17±0.05、7.29±0.07、7.35±0.08,动脉血pH在不同季节没有显著性差异,静脉血pH春季显著低于夏季和秋季。动脉和静脉血二氧化碳分压(Pco2)分别为47.81±14.50mmHg、55.10±13.50mmHg、53.00±10.81mmHg和75.17±31.09mmHg、75.40±20.21mmHg、80.00±17.44mmHg,没有季节性差异;动脉和静脉血氧分压(Po2)分别为76.17±33.24mmHg、78.90±16.61mmHg、88.67±24.94mmHg和7.34±4.07mmHg、10.60±2.76mmHg、10.33±3.56mmHg,没有季节性差异;动脉和静脉血血氧饱和度(SaO2)分别为92.71%±5.00%、94.70%±3.65%、96.00%±4.38%和4.27%±3.03%、9.01%±5.26%、9.67%±6.02%,动脉血SaO2没有季节性差异,而静脉血SaO2春季显著低于夏季和秋季。血液红细胞数(RBC)、血红蛋白(Hb)和红细胞压积(HCT),从春季到冬季依次增加,并具有显著性差异,血清诱导型一氧化氮合成酶(iNOS)活力随着夏季洞道中二氧化碳浓度的增加而显著提高。心肌和骨骼肌肌红蛋白(Mb)含量春季显著高于夏季和秋季,红细胞内2,3-二磷酸甘油酸(2,3-DPG)含量秋季显著高于春季和夏季。上述结果表明:随着洞道中氧气和二氧化碳浓度的季节波动,高原鼢鼠通过调节氧转运有关的功能蛋白含量以及氧代谢有关的生理机制维持组织的氧平衡。
Plateau zokors Myospalax baileyi are one of blind subterranean mole rats. To explore plateau zokors adapting mechanisms to the hypoxic-hypercapnic environment, its blood physiological parameters and the content of myoglobin in cardiac and skeletal muscle were analyzed in spring, summer and autumn seasons. The results indicated that pH of arterial blood and venous blood of plateau zokors in spring, summer and autumn seasons were 7.44 ± 0.09, 7.44 ± 0.05, 7.51 ± 0.07 and 7.17 ± 0.05, 7.29 ± 0.07, 7.35 ± 0.08 respectively. Arterial blood pH had no obvious difference, but pH of venous blood in spring significantly lower than that in summer and autumn. Arterial blood and venous blood Pco2 were 47.81± 14.50 mmHg, 55.10 ± 13.50 mmHg, 53.00 ± 10.81 mmHg and 75.17-± 31.09 mmHg, 75.40 ± 20.21 mmHg, 80.00-± 17.44 mmHg in spring, summer and autumn respectively. It was without obvious seasonal difference. Arterial blood and venous blood Po2 were 76.17 ± 33.24 mmHg, 78.90 ± 16.61 mmHg, 88.67 ± 24.94 mmHg and 7.34 ± 4.07 mmHg, 10.60 ± 2.76 mmHg, 10.33 ± 3.56 mmHg in spring, summer and autumn respectively. It had no obvious seasonal difference. Arterial blood and venous blood SaO2 were 92.71% ± 5.00 % , 94.70 % ± 3.65 %, 96.00 % ±4.38% and 4.27%±3.03%, 9.01%±5.26%, 9.67% ±6.02% in spring, summer and autumn respectively. It was without obvious seasonal difference in arterial blood, but SaO2 of venous blood in spring significantly lower than that in summer and autumn. From spring t to autumn, RBC, Hb and HCT in blood of plateau zokors significantly increased in seasonal order. The activities of iNOS in serum of plateau zokors were increased markedly with increase of carbon dioxide concentration in burrows in summer. In cardiac muscle and skeletal muscle of plateau, the content of Mb was increased obviously in spring. The content of 2, 3-DPG in erythrocyte of plateau zokor was increased obviously in autumn. In conclusion, with seasonal fluctuation of oxygen and carbon dioxide in burrows, plateau zokors maint
出处
《动物学报》
SCIE
CAS
CSCD
北大核心
2006年第5期871-877,共7页
ACTA ZOOLOGICA SINICA
基金
国家自然科学基金资助(No.30460044)~~
关键词
高原鼢鼠
血液生理指标
低氧高二氧化碳
肌红蛋白
Plateau zokor, Myospalax baileyi, Blood physiological parameter, Hypoxia-hypercapania, Myoglobin
