摘要
目的探讨利用细胞学诊断淋巴母细胞性淋巴瘤/白血病的可行性和准确性。方法选择由细胞学初诊、淋巴结或骨髓活检确诊的淋巴母细胞性淋巴瘤/白血病26例,包括浅表淋巴结细针穿刺13例,纵隔包块细针穿刺1例,胸腔积液9例,心包积液1例,脑脊液2例,对所有病例的临床特点、细胞形态和免疫细胞化学进行分析。结果所有病例均查见较多中等偏小的淋巴样肿瘤细胞,其免疫表型为22例(84·6%)表达TdT,22例(84·6%)表达CD99,23例(88·5%)表达CD3ε,3例(11·5%)表达CD20,26例均不表达MPO,Ki-67PI均值为78·6%。结论观察细胞涂片中细胞的形态可以对淋巴母细胞性淋巴瘤/白血病进行初步诊断,结合临床表现和免疫细胞化学结果可进一步提高诊断的准确性和可靠性。
Purpose To discuss the possibility and accuracy of cytological diagnosis of lymphoblastic lymphoma/leukemia. Methods 26 cases （ 13 cases fine needle aspiration of superficial lymph node, 1 case fine needle aspiration of mediastinal mass, 9 cases of pleural fluid, 1 case of pericardial fluid, 2 cases of cerebrospinal fluid） diagnosed by cytologists firstly and conformed by lymph node or bone marrow biopsy were evaluated in this study. To analyze the clinical feature, cytological morphology and immunocytochemistry feature of these cases. Results Medium to small size lymphoid cells could be found in each case. Immunocytochemistry was done for 26 cases, tumor cells in 22 cases express TdT （ 84. 6% ） , tumor cells in 22 cases express CD99 （ 84. 6% ） , 23 cases express CD3ε （88.5%） ,3 cases express CD20（ 11.5% ）. MPO were negative for all cases, the average Ki-67 PI 78. 6%. Conclusions Primary diagnosis could be made just by cytological morphology. If immunocytochemistry are performed, the accuracy and reliability of the results could be improved.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2006年第5期545-548,共4页
Chinese Journal of Clinical and Experimental Pathology
