摘要
目的探讨慢性压迫脊髓损伤减压后早期受压脊髓组织脂质过氧化反应的情况.方法分别测定未压迫组、未减压组及减压后3 h组脊髓组织超氧化物歧化酶(superoxide d ismutase,SOD)的活性及丙二醛(m alond ialdehyde,MDA)的含量.结果与未减压比较,减压后3 h受压脊髓组织丙二醛的含量增加(P<0.01),而超氧化物歧化酶的活性下降(P<0.05).结论慢性压迫脊髓损伤减压后早期受压脊髓组织脂质过氧化反应增强,可能与缺血再灌注损伤有关.
Objective We investigate lipid peroxidation of compressed myeloid tissue at early stage after decompression of chronic compressive spinal cord injury. Method SOD and MDA of compressed myeloid tissue are measured respectively before compression, before decompression and 3 h after decompression. Result Increased MDA while decreased SOD of compressed myeloid tissue at 3 h after decompression than before decompression. Conclusion The increased lipid peroxidation of compressed myeloid tissue at early stage after decompression of chronic compressive spinal cord injury. It is possible that it was resulted from ischemical reperfusion injury.
出处
《昆明医学院学报》
2006年第5期43-45,共3页
Journal of Kunming Medical College
基金
广东省医学科研基金项目(B2004085)
关键词
脊髓损伤
减压术
氧自由基
Spinal injury
Decompression procedure
Oxygen free radical
