摘要
目的观察地西泮（安定）治疗急性酒精中毒兴奋患者的疗效和不良反应（ADR），以加强临床合理用药。方法2000年1月-2006年1月急诊收治的急性酒精中毒兴奋患者共158例，根据采用肌注和静脉不同方式给予地西泮分为肌内注射组91例和静脉注射组67例，两组的年龄、性别、饮酒量、就诊时间以及地西泮使用剂量无显著性差异，组间具有可比性。统计分析地西泮不同给药方式的治疗效果和不良反应。结果肌内注射组有效率为92．31％，没有发生不良反应，危险率为0％。静脉注射组有效率为100％，有3例发生心跳骤停，2例发生误吸、呼吸骤停，不良反应发生率为7．46％。结论对急性酒精中毒兴奋患者应用地西泮镇静治疗，以肌内注射为好，静脉注射有可能诱发严重的医疗意外事件。
Objective To study the effect and adverse drug reaction （ADR） of Diazepam when used to treat acute alcoholism for establishing its rational use. Methods According to the administration of the drug through different routes, 158 patients admitted from Jan. 2000 to Jan. 2006 were divided into two groups- intramuscular group （i. m. , n = 91） and intravenous group （i. v. , n= 67）. There was no significant difference in age, sex, amount of liquor taken, time of seeing doctor, and drug dosage between the two groups. The effect and adverse drug reaction （ADR） of Diazepam were statistically analyzed. Results No ADR occurred in i.m. group and the effective rate was 92.31%. Although the effective rate in i.v. group was 100% patients suffered from cardiac arrest, 2 patients were found to have aspiration and apnea suddenly, and the ratio of ADR was 7.46%. Conclusion It is better to use intramuscular injection rather than intravenous injection in treating acute alcoholism with Diazepam, in order to avoid the serious medical incidents.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2006年第10期1005-1006,共2页
Medical Journal of Chinese People's Liberation Army
关键词
酒精中毒
急性
地西泮
注射
肌肉内
注射
静脉内
alcoholic intoxication
diazepam
injections, intramuscular
injections, intravenous
