摘要
目的研究HA型树脂灌流器治疗重度急性有机磷农药中毒的效果。方法将90例急性重度有机磷农药中毒者根据血液灌流(HP)分为:树脂HP组(治疗组)、炭肾HP组(对照组Ⅰ)、非HP组(对照组Ⅱ),比较治疗组和对照组在昏迷至清醒时间、阿托品化时间、应用阿托品总量、胆碱酯酶活力恢复时间、病死率、住院时间等的差异,比较树脂HP组和炭肾HP组的不良反应。结果树脂HP组和非HP组比较,患者昏迷至清醒时间、阿托品化时间、血清胆碱酯酶活力恢复时间、住院时间明显缩短(P<0.01或0.05),阿托品总量明显降低(P<0.01)、病死率降低(P<0.05);树脂HP组和炭肾HP组疗效、病死率比较差异无显著性(P>0.05),但树脂HP组血小板减少、致热反应的发生率低于炭肾HP组(P均<0.05)。结论应用HA型树脂灌流器治疗重度有机磷中毒疗效良好,且不良反应少。
Objective To summarize the clinical effects of HA - type resin hemoperfusion （HP） apparatus for treatment acute severe organophosphorus pesticide poisoning. Methods 90 patients with acute severe organophosphorus pesticide posoning enrolled in this study were allocated to three groups： resin HP group （therapeutic group）, activated charcoal liP group （control group I） and non - HP group （control group 2）. In these three groups, coma to waking time, atropinization time, total close of atropine, cholinesterase activity recovery time, mortality and in - hospital time were all recorded and compared among these three groups. Compared of adverse reaction between therapeutic group and control group i. Results In comparison to non- HP group, the patients in resin HP group needed shorter time for coma to waking, for atropinization, for serum cholinesterase activation recovery and for in -hospital （ P 〈0.01 or 0.05）, lower total dose of atropine （ P 〈0.01）, lower mortality （ P 〈0.05）. Compared resin group to activated charcoal liP group, there were no statistical significant differences in curative effects and morbility （ P 〉0.05）, but more thrombocytopenia and lower pyrogenic reaction rate in resin HP group were also found （ P 〈0.05）. Conclusion HAtype resin hemoperfusion apparatus in treatment acute organophosphate insecticides poisoning is effective and has less side effect.
出处
《右江民族医学院学报》
2006年第6期931-933,共3页
Journal of Youjiang Medical University for Nationalities
关键词
树脂灌流器
血液灌注
有机硫磷杀虫药/中毒
resin hemoperfusion apparatus
hemoperfusion
organophosphate insecticides/poisoning
