摘要
目的评价比索洛尔/卡维地洛(抗心衰药)治疗充血性心力衰竭的有效性和安全性。方法用多中心随机开放终点盲态法平行对照床试验,选择已接受常规治疗的慢性心力衰竭病人128例(超声LVEF≤40%),随机分为2组,接受比索洛尔或卡维地洛治疗,渐增至最大耐受剂量后,维持4个月。结果治疗后,2组左室射血分数均比用药前明显增加,且左室收缩和舒张期末容量及心胸比例均明显减少,肺瘀血情况和NYHA分级亦明显改善。2组药物不良反应发生率分别为38.16%,46.05%。结论比索洛尔/卡维地洛均可明显改善慢性心衰患者的心功能,耐受性较好。
Objective To evaluate the effects of bisoprilol/carvedilol in patients with chronic left heart failure. Methods One hundred twenty - eight patients with chronic left heart failure [ ejection fraction （EF） less or equal to 40% by eehoeardiography ] were randomly assigned to either bisoprolol or earvedilol group who received conventional- therapy. β - blockers were increased gradually to the target or the tolerant dosages during 3 months and continued for 4 months. Results Compared with pre- medication, both β blockers produced a sustained and significant improvement in New York Heart Association class, left ventrieular （LV） diastolic end diameter and LVEF （ all P 〈 0. 05 ） after the treatment of 6 months. There were no significant differences between two groups for the adverse events. Conclusion Both bisoprilol and earvedilol can improve cardiac function in chronic left heart failure patients.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2006年第4期243-245,共3页
The Chinese Journal of Clinical Pharmacology
关键词
比索洛尔片
卡维地洛片
慢性心力衰竭
心脏功能
bisoprilol tablet
earvedilol tablet
chronic heart failure
cardiac function
